Age of onset of marijuana use impacts inhibitory processing

Staci A. Gruber, Mary Kathryn Dahlgren, Kelly A. Sagar, Atilla Gönenc, William D.S. Killgore

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

Difficulties in the ability to successfully inhibit impulsive behaviors have been reported in marijuana (MJ) smokers, yet few studies have made direct comparisons between early (prior to age 16) and late (age 16 or later) onset MJ smokers, specifically during behavioral inhibition tasks. The current study utilized the Multi-Source Interference Task (MSIT) during functional magnetic resonance imaging (fMRI) in chronic, heavy MJ smokers and healthy non-MJ smoking controls which revealed a more focal pattern of anterior cingulate activity in controls relative to smokers. Early onset smokers had more focal activation but tended to make more errors of commission relative to late onset smokers, suggesting a possible neural adaptation despite difficulty with behavioral inhibition. Further investigation is warranted, as early exposure to MJ may result in reorganization of critical brain regions.

Original languageEnglish (US)
Pages (from-to)89-94
Number of pages6
JournalNeuroscience Letters
Volume511
Issue number2
DOIs
StatePublished - Mar 9 2012
Externally publishedYes

Keywords

  • Age of onset
  • Cognitive control
  • FMRI
  • Inhibition
  • Marijuana

ASJC Scopus subject areas

  • Neuroscience(all)

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