Age-related changes in CD8 T cell homeostasis and immunity to infection

Janko Nikolich-Zugich, Gang Li, Jennifer L. Uhrlaub, Kristin R. Renkema, Megan J Smithey

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Studies of CD8 T cell responses to vaccination or infection with various pathogens in both animal models and human subjects have revealed a markedly consistent array of age-related defects. In general, recent work shows that aged CD8 T cell responses are decreased in magnitude, and show poor differentiation into effector cells, with a reduced arsenal of effector functions. Here we review potential mechanisms underlying these defects. We specifically address phenotypic and numeric changes to the naïve CD8 T cell precursor pool, the impact of persistent viral infection(s) and inflammation, and contributions of the aging environment in which these cells are activated.

Original languageEnglish (US)
Pages (from-to)356-364
Number of pages9
JournalSeminars in Immunology
Volume24
Issue number5
DOIs
StatePublished - Oct 2012

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Immunity
Homeostasis
T-Lymphoid Precursor Cells
T-Lymphocytes
Virus Diseases
Infection
Vaccination
Animal Models
Inflammation

Keywords

  • Aging
  • CD8 T cells
  • Homeostasis
  • Immunity
  • Infection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Age-related changes in CD8 T cell homeostasis and immunity to infection. / Nikolich-Zugich, Janko; Li, Gang; Uhrlaub, Jennifer L.; Renkema, Kristin R.; Smithey, Megan J.

In: Seminars in Immunology, Vol. 24, No. 5, 10.2012, p. 356-364.

Research output: Contribution to journalArticle

Nikolich-Zugich, Janko ; Li, Gang ; Uhrlaub, Jennifer L. ; Renkema, Kristin R. ; Smithey, Megan J. / Age-related changes in CD8 T cell homeostasis and immunity to infection. In: Seminars in Immunology. 2012 ; Vol. 24, No. 5. pp. 356-364.
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