Age-related changes in CD8 T cell homeostasis and immunity to infection

Janko Nikolich-Žugich, Gang Li, Jennifer L. Uhrlaub, Kristin R. Renkema, Megan J. Smithey

Research output: Contribution to journalReview article

69 Scopus citations

Abstract

Studies of CD8 T cell responses to vaccination or infection with various pathogens in both animal models and human subjects have revealed a markedly consistent array of age-related defects. In general, recent work shows that aged CD8 T cell responses are decreased in magnitude, and show poor differentiation into effector cells, with a reduced arsenal of effector functions. Here we review potential mechanisms underlying these defects. We specifically address phenotypic and numeric changes to the naïve CD8 T cell precursor pool, the impact of persistent viral infection(s) and inflammation, and contributions of the aging environment in which these cells are activated.

Original languageEnglish (US)
Pages (from-to)356-364
Number of pages9
JournalSeminars in Immunology
Volume24
Issue number5
DOIs
StatePublished - Oct 1 2012

Keywords

  • Aging
  • CD8 T cells
  • Homeostasis
  • Immunity
  • Infection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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