Age-related connectivity changes in fMRI data from children listening to stories

Prasanna R. Karunanayaka, Scott K. Holland, Vincent J. Schmithorst, Ana Solodkin, E. Elinor Chen, Jerzy P. Szaflarski, Elena M Plante

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

The way humans comprehend narrative speech plays an important part in human development and experience. A group of 313 children with ages 5-18 were subjected to a large-scale functional magnetic resonance imaging (fMRI) study in order to investigate the neural correlates of auditory narrative comprehension. The results were analyzed to investigate the age-related brain activity changes involved in the narrative language comprehension circuitry. We found age-related differences in brain activity which may either reflect changes in local neuroplasticity (of the regions involved) in the developing brain or a more global transformation of brain activity related to neuroplasticity. To investigate this issue, Structural Equation Modeling (SEM) was applied to the results obtained from a group independent component analysis (Schmithorst, V.J., Holland, S.K., et al., 2005. Cognitive modules utilized for narrative comprehension in children: a functional magnetic resonance imaging study. NeuroImage) and the age-related differences were examined in terms of changes in path coefficients between brain regions. The group Independent Component Analysis (ICA) had identified five bilateral task-related components comprising the primary auditory cortex, the mid-superior temporal gyrus, the most posterior aspect of the superior temporal gyrus, the hippocampus, the angular gyrus and the medial aspect of the parietal lobule (precuneus/posterior cingulate). Furthermore, a left-lateralized network (sixth component) was also identified comprising the inferior frontal gyrus (including Broca's area), the inferior parietal lobule, and the medial temporal gyrus. The components (brain regions) for the SEM were identified based on the ICA maps and the results are discussed in light of recent neuroimaging studies corroborating the functional segregation of Broca's and Wernicke's areas and the important role played by the right hemisphere in narrative comprehension. The classical Wernicke-Geschwind (WG) model for speech processing is expanded to a two-route model involving a direct route between Broca's and Wernicke's area and an indirect route involving the parietal lobe.

Original languageEnglish (US)
Pages (from-to)349-360
Number of pages12
JournalNeuroImage
Volume34
Issue number1
DOIs
StatePublished - Jan 1 2007

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Parietal Lobe
Magnetic Resonance Imaging
Brain
Neuronal Plasticity
Temporal Lobe
Parahippocampal Gyrus
Auditory Cortex
Gyrus Cinguli
Human Development
Prefrontal Cortex
Neuroimaging
Language
Broca Area
Wernicke Area

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Karunanayaka, P. R., Holland, S. K., Schmithorst, V. J., Solodkin, A., Chen, E. E., Szaflarski, J. P., & Plante, E. M. (2007). Age-related connectivity changes in fMRI data from children listening to stories. NeuroImage, 34(1), 349-360. https://doi.org/10.1016/j.neuroimage.2006.08.028

Age-related connectivity changes in fMRI data from children listening to stories. / Karunanayaka, Prasanna R.; Holland, Scott K.; Schmithorst, Vincent J.; Solodkin, Ana; Chen, E. Elinor; Szaflarski, Jerzy P.; Plante, Elena M.

In: NeuroImage, Vol. 34, No. 1, 01.01.2007, p. 349-360.

Research output: Contribution to journalArticle

Karunanayaka, PR, Holland, SK, Schmithorst, VJ, Solodkin, A, Chen, EE, Szaflarski, JP & Plante, EM 2007, 'Age-related connectivity changes in fMRI data from children listening to stories', NeuroImage, vol. 34, no. 1, pp. 349-360. https://doi.org/10.1016/j.neuroimage.2006.08.028
Karunanayaka PR, Holland SK, Schmithorst VJ, Solodkin A, Chen EE, Szaflarski JP et al. Age-related connectivity changes in fMRI data from children listening to stories. NeuroImage. 2007 Jan 1;34(1):349-360. https://doi.org/10.1016/j.neuroimage.2006.08.028
Karunanayaka, Prasanna R. ; Holland, Scott K. ; Schmithorst, Vincent J. ; Solodkin, Ana ; Chen, E. Elinor ; Szaflarski, Jerzy P. ; Plante, Elena M. / Age-related connectivity changes in fMRI data from children listening to stories. In: NeuroImage. 2007 ; Vol. 34, No. 1. pp. 349-360.
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