Age-related left ventricular function in the mouse: Analysis based on in vivo pressure-volume relationships

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111 Scopus citations

Abstract

Our study compared left ventricular (LV) function between senescent and young adult mice through in situ presure-volume loop analysis. Two groups of mice (n = 9 each), 6-mo-old and 1-mo-old (senescent) mice, were anesthetized with urethan and α-chloralose, and their LV were instrumented with a Millar 1.4-Fr conductance micromanometer catheter for the acquisition of the pressure-volume loops. The senescent mice had a significantly decreased contractile function related to load-dependent parameters, including stroke volume index, maximum derivative of change in systolic pressure over time. The load-independent parameters, preload recruitable stroke work and the slope (end-systolic volume elastance) of the end-systolic pressure-volume relationship, were significantly decreased in the senescent mice. Heart rate and arterial elastance were not different between the two groups; however, the ventricular-to-vascular coupling ratio (ratio of elastance of artery to end-systolic volume elastance) was increased by threefold in the senescent mice (P < 0.001). Thus there were significant decreases in contractile function in the senescent mouse heart that appeared to be related to reduced mechanical efficiency but not related to arterial elastance.

Original languageEnglish (US)
Pages (from-to)H1906-H1913
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume277
Issue number5 46-5
DOIs
StatePublished - Nov 1999

Keywords

  • Conductance catheter
  • End-systolic pressure-volume relationship
  • Preload recruitable stroke work
  • Senescence

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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