Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections

Research output: Contribution to journalReview article

254 Scopus citations

Abstract

A diverse and well-balanced repertoire of T cells is thought to be crucial for the efficacious defence against infection with new or re-emerging pathogens throughout life. In the last third of the mammalian lifespan, the maintenance of a balanced T-cell repertoire becomes highly challenging because of the changes in T-cell production and consumption. In this Review, I question whether latent persistent pathogens might be key factors that drive this imbalance and whether they determine the extent of age-associated immune deficiency.

Original languageEnglish (US)
Pages (from-to)512-522
Number of pages11
JournalNature Reviews Immunology
Volume8
Issue number7
DOIs
StatePublished - Jul 1 2008

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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