TY - JOUR
T1 - Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections
AU - Nikolich-Žugich, Janko
N1 - Funding Information:
I thank the members of my laboratory for stimulating discussions (in particular, L. Cicin-Sain, A. Lang and B. Rudd) and A. Townsend for help with the original illustrations. I also acknowledge support from the US Public Health Service awards AG20719, AG21384, AG23664 and N0150027 from the National Institute on Aging and National Institute of Allergy and Infectious Diseases and RR 0163 (the Core National Primate Research Center award to Oregon National Primate Research Centre) from the National Institutes of Health, USA.
PY - 2008/7
Y1 - 2008/7
N2 - A diverse and well-balanced repertoire of T cells is thought to be crucial for the efficacious defence against infection with new or re-emerging pathogens throughout life. In the last third of the mammalian lifespan, the maintenance of a balanced T-cell repertoire becomes highly challenging because of the changes in T-cell production and consumption. In this Review, I question whether latent persistent pathogens might be key factors that drive this imbalance and whether they determine the extent of age-associated immune deficiency.
AB - A diverse and well-balanced repertoire of T cells is thought to be crucial for the efficacious defence against infection with new or re-emerging pathogens throughout life. In the last third of the mammalian lifespan, the maintenance of a balanced T-cell repertoire becomes highly challenging because of the changes in T-cell production and consumption. In this Review, I question whether latent persistent pathogens might be key factors that drive this imbalance and whether they determine the extent of age-associated immune deficiency.
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U2 - 10.1038/nri2318
DO - 10.1038/nri2318
M3 - Review article
C2 - 18469829
AN - SCOPUS:46249132015
VL - 8
SP - 512
EP - 522
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
SN - 1474-1733
IS - 7
ER -