Aggressive doxorubicin-containing regimen (prednisone, methotrexate, 5-FU, doxorubicin, and cyclophosphamide; PM-FAC) in disseminated estrogen receptor-negative breast cancer

J. Mortimer, R. B. Livingston, I. J. Hardesty, C. W. Groppe, J. D. Purvis, M. Gupta, N. Flournoy

Research output: Contribution to journalArticle

4 Scopus citations


Twenty-seven women with disseminated estrogen receptor-negative breast cancer received an aggressive chemotherapy program of prednisone, methotrexate, 5-FU, doxorubicin, and cyclophosphamide. Responses were achieved in 21 of 26 (81%) evaluable patients, eight (31%) of whom had complete responses. The median survival was 17 months. Despite the favorable overall response and a significant number of complete responses, all patients eventually relapsed. Although most patients relapsed systemically, two relapsed initially in the CNS.

Original languageEnglish (US)
Pages (from-to)1017-1018
Number of pages2
JournalCancer Treatment Reports
Issue number7-8
StatePublished - Oct 18 1984


ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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