Aging in Rhesus Macaques Is Associated With Changes in Novelty Preference and Altered Saccade Dynamics

Nathan Insel, María Luisa Ruiz-Luna, Michelle Permenter, Julie Vogt, Cynthia A. Erickson, Carol A Barnes

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Studies demonstrating recognition deficits with aging often use tasks in which subjects have an incentive to correctly encode or retrieve the experimental stimuli. In contrast to these tasks, which may engage strategic encoding and retrieval processes, the visual paired comparison (VPC) task measures spontaneous eye movements made toward a novel as compared with familiar stimulus. In the present study, seven rhesus macaques aged 6 to 30 years exhibited a dramatic age-dependent decline in preference for a novel image compared with one presented seconds earlier. The age effect could not be accounted for by memory deficits alone, because it was present even when familiarization preceded test by 1 second. It also could not be explained by an encoding deficit, because the effect persisted with increased familiarity of the sample stimulus. Reduced novelty preference did correlate with eye movement variables, including reaction time distributions and saccade frequency. At long delay intervals (24 or 48 hours) aging was paradoxically associated with increased novelty preference. Several explanations for the age effect are considered, including the possible role of dopamine.

Original languageEnglish (US)
Pages (from-to)1328-1342
Number of pages15
JournalBehavioral Neuroscience
Volume122
Issue number6
DOIs
StatePublished - Dec 2008

Fingerprint

Saccades
Eye Movements
Macaca mulatta
Matched-Pair Analysis
Memory Disorders
Reaction Time
Motivation
Dopamine
Recognition (Psychology)

Keywords

  • aging
  • attention
  • novelty
  • recognition memory
  • saccades

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Aging in Rhesus Macaques Is Associated With Changes in Novelty Preference and Altered Saccade Dynamics. / Insel, Nathan; Ruiz-Luna, María Luisa; Permenter, Michelle; Vogt, Julie; Erickson, Cynthia A.; Barnes, Carol A.

In: Behavioral Neuroscience, Vol. 122, No. 6, 12.2008, p. 1328-1342.

Research output: Contribution to journalArticle

Insel, Nathan ; Ruiz-Luna, María Luisa ; Permenter, Michelle ; Vogt, Julie ; Erickson, Cynthia A. ; Barnes, Carol A. / Aging in Rhesus Macaques Is Associated With Changes in Novelty Preference and Altered Saccade Dynamics. In: Behavioral Neuroscience. 2008 ; Vol. 122, No. 6. pp. 1328-1342.
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