Agouti-related protein promoter variant associated with leanness and decreased risk for diabetes in West Africans

C. Bonilla, R. K. Panguluri, L. Taliaferro-Smith, G. Argyropoulos, G. Chen, A. A. Adeyemo, A. Amoah, S. Owusu, J. Acheampong, K. Agyenim-Boateng, B. A. Eghan, J. Oli, G. Okafor, F. Abbiyesuku, T. Johnson, T. Rufus, O. Fasanmade, Y. Chen, F. S. Collins, G. M. Dunston & 2 others C. Rotimi, Rick A Kittles

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objective: The role of the central melanocortin system in the development of obesity has been extensively studied. Single-nucleotide polymorphisms (SNPs) within several candidate genes have been associated with food intake and obesity-related phenotypes; however, few of these associations have been replicated. SNPs in the agouti-related protein (AGRP) gene coding (Ala67Thr, 199G/A) and promoter (-38C/T) have been reported to be associated with body mass index (BMI), fat mass (FM) and percent body fat, in populations of European and African descent. In this study, we evaluated the association between the functional AGRP -38C/T promoter SNP and weight-related traits, namely BMI, FM and fat-free mass (FFM), as well as diabetes status. Design: An association study of the AGRP -38C/T SNP and indices of obesity and diabetes status. Subjects: A well-characterized population of 538 West Africans from Ghana and Nigeria recruited in the AADM (Africa America Diabetes Mellitus) study (mean age 52 years, 41.3% males, 71% diabetic). Measurements: Genotyping of the AGRP -38C/T SNP, BMI, FM, FFM and fasting plasma glucose. Results: Women carrying two copies of the variant T allele had significantly lower BMI (OR = 0.47; 95% CI, 0.25-0.87). Also, men with at least one copy of the variant T allele were over two times less likely to be diabetic than other men (OR = 0.44; 95% CI, 0.22-0.89). Conclusion: Our results replicate previous findings and implicate the AGRP -38C/T SNP in the regulation of body weight in West Africans.

Original languageEnglish (US)
Pages (from-to)715-721
Number of pages7
JournalInternational Journal of Obesity
Volume30
Issue number4
DOIs
StatePublished - Apr 2006
Externally publishedYes

Fingerprint

Agouti-Related Protein
Agouti
Thinness
risk reduction
single nucleotide polymorphism
Single Nucleotide Polymorphism
diabetes
promoter regions
Fats
body mass index
Body Mass Index
lipids
obesity
proteins
Obesity
Alleles
Melanocortins
alleles
Ghana
diabetes mellitus

Keywords

  • AGRP
  • Diabetes
  • West Africans

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Agouti-related protein promoter variant associated with leanness and decreased risk for diabetes in West Africans. / Bonilla, C.; Panguluri, R. K.; Taliaferro-Smith, L.; Argyropoulos, G.; Chen, G.; Adeyemo, A. A.; Amoah, A.; Owusu, S.; Acheampong, J.; Agyenim-Boateng, K.; Eghan, B. A.; Oli, J.; Okafor, G.; Abbiyesuku, F.; Johnson, T.; Rufus, T.; Fasanmade, O.; Chen, Y.; Collins, F. S.; Dunston, G. M.; Rotimi, C.; Kittles, Rick A.

In: International Journal of Obesity, Vol. 30, No. 4, 04.2006, p. 715-721.

Research output: Contribution to journalArticle

Bonilla, C, Panguluri, RK, Taliaferro-Smith, L, Argyropoulos, G, Chen, G, Adeyemo, AA, Amoah, A, Owusu, S, Acheampong, J, Agyenim-Boateng, K, Eghan, BA, Oli, J, Okafor, G, Abbiyesuku, F, Johnson, T, Rufus, T, Fasanmade, O, Chen, Y, Collins, FS, Dunston, GM, Rotimi, C & Kittles, RA 2006, 'Agouti-related protein promoter variant associated with leanness and decreased risk for diabetes in West Africans', International Journal of Obesity, vol. 30, no. 4, pp. 715-721. https://doi.org/10.1038/sj.ijo.0803047
Bonilla, C. ; Panguluri, R. K. ; Taliaferro-Smith, L. ; Argyropoulos, G. ; Chen, G. ; Adeyemo, A. A. ; Amoah, A. ; Owusu, S. ; Acheampong, J. ; Agyenim-Boateng, K. ; Eghan, B. A. ; Oli, J. ; Okafor, G. ; Abbiyesuku, F. ; Johnson, T. ; Rufus, T. ; Fasanmade, O. ; Chen, Y. ; Collins, F. S. ; Dunston, G. M. ; Rotimi, C. ; Kittles, Rick A. / Agouti-related protein promoter variant associated with leanness and decreased risk for diabetes in West Africans. In: International Journal of Obesity. 2006 ; Vol. 30, No. 4. pp. 715-721.
@article{bb6b73418aea4187a729ffce52fde917,
title = "Agouti-related protein promoter variant associated with leanness and decreased risk for diabetes in West Africans",
abstract = "Objective: The role of the central melanocortin system in the development of obesity has been extensively studied. Single-nucleotide polymorphisms (SNPs) within several candidate genes have been associated with food intake and obesity-related phenotypes; however, few of these associations have been replicated. SNPs in the agouti-related protein (AGRP) gene coding (Ala67Thr, 199G/A) and promoter (-38C/T) have been reported to be associated with body mass index (BMI), fat mass (FM) and percent body fat, in populations of European and African descent. In this study, we evaluated the association between the functional AGRP -38C/T promoter SNP and weight-related traits, namely BMI, FM and fat-free mass (FFM), as well as diabetes status. Design: An association study of the AGRP -38C/T SNP and indices of obesity and diabetes status. Subjects: A well-characterized population of 538 West Africans from Ghana and Nigeria recruited in the AADM (Africa America Diabetes Mellitus) study (mean age 52 years, 41.3{\%} males, 71{\%} diabetic). Measurements: Genotyping of the AGRP -38C/T SNP, BMI, FM, FFM and fasting plasma glucose. Results: Women carrying two copies of the variant T allele had significantly lower BMI (OR = 0.47; 95{\%} CI, 0.25-0.87). Also, men with at least one copy of the variant T allele were over two times less likely to be diabetic than other men (OR = 0.44; 95{\%} CI, 0.22-0.89). Conclusion: Our results replicate previous findings and implicate the AGRP -38C/T SNP in the regulation of body weight in West Africans.",
keywords = "AGRP, Diabetes, West Africans",
author = "C. Bonilla and Panguluri, {R. K.} and L. Taliaferro-Smith and G. Argyropoulos and G. Chen and Adeyemo, {A. A.} and A. Amoah and S. Owusu and J. Acheampong and K. Agyenim-Boateng and Eghan, {B. A.} and J. Oli and G. Okafor and F. Abbiyesuku and T. Johnson and T. Rufus and O. Fasanmade and Y. Chen and Collins, {F. S.} and Dunston, {G. M.} and C. Rotimi and Kittles, {Rick A}",
year = "2006",
month = "4",
doi = "10.1038/sj.ijo.0803047",
language = "English (US)",
volume = "30",
pages = "715--721",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "Nature Publishing Group",
number = "4",

}

TY - JOUR

T1 - Agouti-related protein promoter variant associated with leanness and decreased risk for diabetes in West Africans

AU - Bonilla, C.

AU - Panguluri, R. K.

AU - Taliaferro-Smith, L.

AU - Argyropoulos, G.

AU - Chen, G.

AU - Adeyemo, A. A.

AU - Amoah, A.

AU - Owusu, S.

AU - Acheampong, J.

AU - Agyenim-Boateng, K.

AU - Eghan, B. A.

AU - Oli, J.

AU - Okafor, G.

AU - Abbiyesuku, F.

AU - Johnson, T.

AU - Rufus, T.

AU - Fasanmade, O.

AU - Chen, Y.

AU - Collins, F. S.

AU - Dunston, G. M.

AU - Rotimi, C.

AU - Kittles, Rick A

PY - 2006/4

Y1 - 2006/4

N2 - Objective: The role of the central melanocortin system in the development of obesity has been extensively studied. Single-nucleotide polymorphisms (SNPs) within several candidate genes have been associated with food intake and obesity-related phenotypes; however, few of these associations have been replicated. SNPs in the agouti-related protein (AGRP) gene coding (Ala67Thr, 199G/A) and promoter (-38C/T) have been reported to be associated with body mass index (BMI), fat mass (FM) and percent body fat, in populations of European and African descent. In this study, we evaluated the association between the functional AGRP -38C/T promoter SNP and weight-related traits, namely BMI, FM and fat-free mass (FFM), as well as diabetes status. Design: An association study of the AGRP -38C/T SNP and indices of obesity and diabetes status. Subjects: A well-characterized population of 538 West Africans from Ghana and Nigeria recruited in the AADM (Africa America Diabetes Mellitus) study (mean age 52 years, 41.3% males, 71% diabetic). Measurements: Genotyping of the AGRP -38C/T SNP, BMI, FM, FFM and fasting plasma glucose. Results: Women carrying two copies of the variant T allele had significantly lower BMI (OR = 0.47; 95% CI, 0.25-0.87). Also, men with at least one copy of the variant T allele were over two times less likely to be diabetic than other men (OR = 0.44; 95% CI, 0.22-0.89). Conclusion: Our results replicate previous findings and implicate the AGRP -38C/T SNP in the regulation of body weight in West Africans.

AB - Objective: The role of the central melanocortin system in the development of obesity has been extensively studied. Single-nucleotide polymorphisms (SNPs) within several candidate genes have been associated with food intake and obesity-related phenotypes; however, few of these associations have been replicated. SNPs in the agouti-related protein (AGRP) gene coding (Ala67Thr, 199G/A) and promoter (-38C/T) have been reported to be associated with body mass index (BMI), fat mass (FM) and percent body fat, in populations of European and African descent. In this study, we evaluated the association between the functional AGRP -38C/T promoter SNP and weight-related traits, namely BMI, FM and fat-free mass (FFM), as well as diabetes status. Design: An association study of the AGRP -38C/T SNP and indices of obesity and diabetes status. Subjects: A well-characterized population of 538 West Africans from Ghana and Nigeria recruited in the AADM (Africa America Diabetes Mellitus) study (mean age 52 years, 41.3% males, 71% diabetic). Measurements: Genotyping of the AGRP -38C/T SNP, BMI, FM, FFM and fasting plasma glucose. Results: Women carrying two copies of the variant T allele had significantly lower BMI (OR = 0.47; 95% CI, 0.25-0.87). Also, men with at least one copy of the variant T allele were over two times less likely to be diabetic than other men (OR = 0.44; 95% CI, 0.22-0.89). Conclusion: Our results replicate previous findings and implicate the AGRP -38C/T SNP in the regulation of body weight in West Africans.

KW - AGRP

KW - Diabetes

KW - West Africans

UR - http://www.scopus.com/inward/record.url?scp=33645470268&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645470268&partnerID=8YFLogxK

U2 - 10.1038/sj.ijo.0803047

DO - 10.1038/sj.ijo.0803047

M3 - Article

VL - 30

SP - 715

EP - 721

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

IS - 4

ER -