AIDS, Kaposi sarcoma, and the lymphatic system: Update and reflections

M. H. Witte, C. L. Witte, D. L. Way, M. Fiala

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6 Scopus citations

Abstract

Based on ongoing basic and clinical investigations,further evidence is presented that the AIDS-Kaposi sarcoma (AIDS-KS) complex involves a progressive disturbance of the blood-lymph circulatory loop of fluid, macromolecules, and migrating cells. We first surveyed the spectrum of vascular abnormalities including Kaposi sarcoma (KS) found in the AIDS/ARC population, then non-invasively imaged lymphatic system abnormalities in AIDS-KS by whole body lymphangioscintigraphy, and finally examined the biologic behavior of AIDS-KS cells in long-term tissue culture. These observations are viewed in terms of the lymphatic and blood vascular route of entry and transport of free and cell-associated virus and other opportunistic pathogens as well as poorly understood host endothelial-immune system interactions.

Original languageEnglish (US)
Pages (from-to)73-80
Number of pages8
JournalLymphology
Volume23
Issue number2
StatePublished - Jan 1 1990

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Hematology

Cite this

Witte, M. H., Witte, C. L., Way, D. L., & Fiala, M. (1990). AIDS, Kaposi sarcoma, and the lymphatic system: Update and reflections. Lymphology, 23(2), 73-80.