Air pollution and biomarkers of systemic inflammation and tissue repair in COPD patients

Payam Dadvand, Mark J. Nieuwenhuijsen, Àlvar Agustí, Jordi De Batlle, Marta Benet, Rob Beelen, Marta Cirach, David Martinez, Gerard Hoek, Xavier Basagaña, Antoni Ferrer, Jaume Ferrer, Robert Rodriguez-Roisin, Jaume Sauleda, Stefano Guerra, Josep M. Antó, Judith Garcia-Aymerich

Research output: Contribution to journalArticle

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Abstract

The origin(s) of systemic inflammation in patients with chronic obstructive pulmonary disease (COPD) is unclear. We investigated the impact of exposure to ambient air pollution on systemic biomarkers of inflammation (C-reactive protein (CRP), tumour necrosis factor-α, interleukin (IL)-6, IL-8 and fibrinogen) and tissue repair (hepatocyte growth factor (HGF)) in 242 clinically stable COPD patients (mean age 67.8 years and forced expiratory volume in 1 s 71.3% predicted) in Barcelona, Spain, in 2004-2006. A spatiotemporal exposure assessment framework was applied to predict ambient nitrogen dioxide (NO 2) and levels of particles with a 50% cut-off aerodynamic diameter of 2.5 μm (PM2.5) at each participant's home address during 10 periods of 24 h (lags 1-10) and 1 year prior to the blood sampling date. We used linear regression models to estimate associations between biomarkers and exposure levels. An interquartile range (IQR) increase in NO2 exposure in lag 5 was associated with 51%, 10% and 9% increases in CRP, fibrinogen and HGF levels respectively. We also observed 12% and 8% increases in IL-8 associated with an IQR increase in NO2 exposure in lag 3 and over the year before sampling, respectively. These increases were larger in former smokers. The results for PM2.5 were not conclusive. These results show that exposure to ambient NO2 increases systemic inflammation in COPD patients, especially in former smokers.

Original languageEnglish (US)
Pages (from-to)603-613
Number of pages11
JournalEuropean Respiratory Journal
Volume44
Issue number3
DOIs
StatePublished - Sep 1 2014

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Air Pollution
Chronic Obstructive Pulmonary Disease
Hepatocyte Growth Factor
Biomarkers
Inflammation
Interleukin-8
C-Reactive Protein
Fibrinogen
Linear Models
Nitrogen Dioxide
Forced Expiratory Volume
Spain
Interleukin-6
Tumor Necrosis Factor-alpha

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Dadvand, P., Nieuwenhuijsen, M. J., Agustí, À., De Batlle, J., Benet, M., Beelen, R., ... Garcia-Aymerich, J. (2014). Air pollution and biomarkers of systemic inflammation and tissue repair in COPD patients. European Respiratory Journal, 44(3), 603-613. https://doi.org/10.1183/09031936.00168813

Air pollution and biomarkers of systemic inflammation and tissue repair in COPD patients. / Dadvand, Payam; Nieuwenhuijsen, Mark J.; Agustí, Àlvar; De Batlle, Jordi; Benet, Marta; Beelen, Rob; Cirach, Marta; Martinez, David; Hoek, Gerard; Basagaña, Xavier; Ferrer, Antoni; Ferrer, Jaume; Rodriguez-Roisin, Robert; Sauleda, Jaume; Guerra, Stefano; Antó, Josep M.; Garcia-Aymerich, Judith.

In: European Respiratory Journal, Vol. 44, No. 3, 01.09.2014, p. 603-613.

Research output: Contribution to journalArticle

Dadvand, P, Nieuwenhuijsen, MJ, Agustí, À, De Batlle, J, Benet, M, Beelen, R, Cirach, M, Martinez, D, Hoek, G, Basagaña, X, Ferrer, A, Ferrer, J, Rodriguez-Roisin, R, Sauleda, J, Guerra, S, Antó, JM & Garcia-Aymerich, J 2014, 'Air pollution and biomarkers of systemic inflammation and tissue repair in COPD patients', European Respiratory Journal, vol. 44, no. 3, pp. 603-613. https://doi.org/10.1183/09031936.00168813
Dadvand P, Nieuwenhuijsen MJ, Agustí À, De Batlle J, Benet M, Beelen R et al. Air pollution and biomarkers of systemic inflammation and tissue repair in COPD patients. European Respiratory Journal. 2014 Sep 1;44(3):603-613. https://doi.org/10.1183/09031936.00168813
Dadvand, Payam ; Nieuwenhuijsen, Mark J. ; Agustí, Àlvar ; De Batlle, Jordi ; Benet, Marta ; Beelen, Rob ; Cirach, Marta ; Martinez, David ; Hoek, Gerard ; Basagaña, Xavier ; Ferrer, Antoni ; Ferrer, Jaume ; Rodriguez-Roisin, Robert ; Sauleda, Jaume ; Guerra, Stefano ; Antó, Josep M. ; Garcia-Aymerich, Judith. / Air pollution and biomarkers of systemic inflammation and tissue repair in COPD patients. In: European Respiratory Journal. 2014 ; Vol. 44, No. 3. pp. 603-613.
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