Airway Coccidioidomycosis - Report of cases and review

Andrea Polesky, Carl M. Kirsch, Linda S. Snyder, Philip LoBue, Frank T. Kagawa, Brian J. Dykstra, John H. Wehner, Antonino Catanzaro, Neil M. Ampel, David A. Stevens

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Infection due to Coccidioides immitis usually begins in the lungs. Despite the initial pulmonary portal of entry, endotracheal and endobronchial coccidioidomycosis has rarely been described. Since the introduction of fiberoptic bronchoscopy and the AIDS epidemic, more C. immitis lesions of the large airways have been noted. We present data on 38 cases of coccidioidomycosis 2of the airways, including 6 cases detailed from our own experience and 32 from the literature. Direct infection of the airways (28 cases) is a more common mechanism of airways disease than is erosion into the airways from a lymph node (5 cases). Bronchoscopic findings vary and may show mucosal involvement or intrinsic obstruction. Endotracheal and endobronchial disease is not a self-limited disease and requires antifungal therapy. Disseminated disease in these patients is common. Coccidioidomycosis must be considered in the differential diagnosis of airway pathology.

Original languageEnglish (US)
Pages (from-to)1273-1280
Number of pages8
JournalClinical Infectious Diseases
Volume28
Issue number6
DOIs
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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    Polesky, A., Kirsch, C. M., Snyder, L. S., LoBue, P., Kagawa, F. T., Dykstra, B. J., Wehner, J. H., Catanzaro, A., Ampel, N. M., & Stevens, D. A. (1999). Airway Coccidioidomycosis - Report of cases and review. Clinical Infectious Diseases, 28(6), 1273-1280. https://doi.org/10.1086/514778