Airway responsiveness to cold, dry air in normal infants.

D. E. Geller, Wayne J Morgan, K. A. Cota, Anne L Wright, L. M. Taussig

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Reactive airway disease may be related to genetic, infectious, and environmental factors. The latter two have been well documented, but there are no data on nonspecific airway responsiveness in normal infants prior to any insult to the respiratory tract. We measured forced expiratory flow by the thoracic compression technique and lung volume in 30 normal infants before and after challenge with cold, dry air (CDA) and compared the results with those in 12 infants who did not receive CDA challenge. As a group, infants challenged with CDA had a mean decrease in VmaxFRC of 17.9 +/- 24.1% SD. This was significantly different (P less than 0.01) from the lack of change (+ 1.3 +/- 18.1% SD) seen in the control group. We conclude that nonspecific airway reactivity may exist from early infancy and may predate any known lung injury. The relationship of this airway responsiveness to subsequent reactive airway disease and other respiratory illnesses is unknown and requires longitudinal study.

Original languageEnglish (US)
Pages (from-to)90-97
Number of pages8
JournalPediatric Pulmonology
Volume4
Issue number2
StatePublished - 1988

Fingerprint

Air
Lung Injury
Prednisolone
Respiratory System
Longitudinal Studies
Thorax
Lung
Control Groups

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Airway responsiveness to cold, dry air in normal infants. / Geller, D. E.; Morgan, Wayne J; Cota, K. A.; Wright, Anne L; Taussig, L. M.

In: Pediatric Pulmonology, Vol. 4, No. 2, 1988, p. 90-97.

Research output: Contribution to journalArticle

Geller, DE, Morgan, WJ, Cota, KA, Wright, AL & Taussig, LM 1988, 'Airway responsiveness to cold, dry air in normal infants.', Pediatric Pulmonology, vol. 4, no. 2, pp. 90-97.
Geller, D. E. ; Morgan, Wayne J ; Cota, K. A. ; Wright, Anne L ; Taussig, L. M. / Airway responsiveness to cold, dry air in normal infants. In: Pediatric Pulmonology. 1988 ; Vol. 4, No. 2. pp. 90-97.
@article{51ae70ddbf7e459c9dbcd26741fed37a,
title = "Airway responsiveness to cold, dry air in normal infants.",
abstract = "Reactive airway disease may be related to genetic, infectious, and environmental factors. The latter two have been well documented, but there are no data on nonspecific airway responsiveness in normal infants prior to any insult to the respiratory tract. We measured forced expiratory flow by the thoracic compression technique and lung volume in 30 normal infants before and after challenge with cold, dry air (CDA) and compared the results with those in 12 infants who did not receive CDA challenge. As a group, infants challenged with CDA had a mean decrease in VmaxFRC of 17.9 +/- 24.1{\%} SD. This was significantly different (P less than 0.01) from the lack of change (+ 1.3 +/- 18.1{\%} SD) seen in the control group. We conclude that nonspecific airway reactivity may exist from early infancy and may predate any known lung injury. The relationship of this airway responsiveness to subsequent reactive airway disease and other respiratory illnesses is unknown and requires longitudinal study.",
author = "Geller, {D. E.} and Morgan, {Wayne J} and Cota, {K. A.} and Wright, {Anne L} and Taussig, {L. M.}",
year = "1988",
language = "English (US)",
volume = "4",
pages = "90--97",
journal = "Pediatric Pulmonology",
issn = "8755-6863",
publisher = "Wiley-Liss Inc.",
number = "2",

}

TY - JOUR

T1 - Airway responsiveness to cold, dry air in normal infants.

AU - Geller, D. E.

AU - Morgan, Wayne J

AU - Cota, K. A.

AU - Wright, Anne L

AU - Taussig, L. M.

PY - 1988

Y1 - 1988

N2 - Reactive airway disease may be related to genetic, infectious, and environmental factors. The latter two have been well documented, but there are no data on nonspecific airway responsiveness in normal infants prior to any insult to the respiratory tract. We measured forced expiratory flow by the thoracic compression technique and lung volume in 30 normal infants before and after challenge with cold, dry air (CDA) and compared the results with those in 12 infants who did not receive CDA challenge. As a group, infants challenged with CDA had a mean decrease in VmaxFRC of 17.9 +/- 24.1% SD. This was significantly different (P less than 0.01) from the lack of change (+ 1.3 +/- 18.1% SD) seen in the control group. We conclude that nonspecific airway reactivity may exist from early infancy and may predate any known lung injury. The relationship of this airway responsiveness to subsequent reactive airway disease and other respiratory illnesses is unknown and requires longitudinal study.

AB - Reactive airway disease may be related to genetic, infectious, and environmental factors. The latter two have been well documented, but there are no data on nonspecific airway responsiveness in normal infants prior to any insult to the respiratory tract. We measured forced expiratory flow by the thoracic compression technique and lung volume in 30 normal infants before and after challenge with cold, dry air (CDA) and compared the results with those in 12 infants who did not receive CDA challenge. As a group, infants challenged with CDA had a mean decrease in VmaxFRC of 17.9 +/- 24.1% SD. This was significantly different (P less than 0.01) from the lack of change (+ 1.3 +/- 18.1% SD) seen in the control group. We conclude that nonspecific airway reactivity may exist from early infancy and may predate any known lung injury. The relationship of this airway responsiveness to subsequent reactive airway disease and other respiratory illnesses is unknown and requires longitudinal study.

UR - http://www.scopus.com/inward/record.url?scp=0023779209&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023779209&partnerID=8YFLogxK

M3 - Article

C2 - 3380581

AN - SCOPUS:0023779209

VL - 4

SP - 90

EP - 97

JO - Pediatric Pulmonology

JF - Pediatric Pulmonology

SN - 8755-6863

IS - 2

ER -