Alcohol use and risk of non-Hodgkin's lymphoma among Connecticut women (United States)

Lindsay McOmber Morton, Theodore R. Holford, Brian Leaderer, Yawei Zhang, Shelia Hoar Zahm, Peter Boyle, Stuart D Flynn, Giovanni Tallini, Patricia H. Owens, Bing Zhang, Tongzhang Zheng

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Objective: Incidence rates of non-Hodgkin's lymphoma (NHL) have risen dramatically over the past several decades; however, the etiology of NHL remains largely unknown. Previous studies of the relationship between alcohol consumption and NHL have yielded conflicting results. Data from a population-based case-control study among women in Connecticut were analyzed to determine the potential impact of alcohol consumption on risk of NHL. Methods: The study included 601 histologically confirmed, incident cases of NHL and 718 population-based controls. In-person interviews were administered using standardized, structured questionnaires to collect data on history of consumption for beer, wine, and liquor. Results: When compared to non-drinkers, women who reported consumption of at least 12 drinks per year of any type of alcohol experienced slightly reduced risk of NHL (OR: 0.82; 95% CI: 0.65-1.04). Further stratification by alcohol type revealed that the inverse association was mainly limited to wine consumption (OR: 0.75; 95% CI: 0.59-0.96), with no clear association for beer or liquor consumption. Risk of NHL was further reduced with increasing duration of wine consumption (p for linear trend = 0.02). Consumption of wine for greater than 40 years was associated with approximately 40% reduction in risk (OR: 0.63; 95% CI: 0.44-0.91). Conclusion: Our results are consistent with several recent epidemiologic studies that have also suggested an inverse association between wine consumption and risk of NHL. The reduction in risk of NHL associated with increased duration of wine consumption warrants further investigation in other populations.

Original languageEnglish (US)
Pages (from-to)687-694
Number of pages8
JournalCancer Causes and Control
Volume14
Issue number7
DOIs
StatePublished - Sep 2003
Externally publishedYes

Fingerprint

Non-Hodgkin's Lymphoma
Alcohols
Wine
Risk Reduction Behavior
Alcohol Drinking
Population Control
Population
Case-Control Studies
Epidemiologic Studies
Interviews
Incidence

Keywords

  • Alcohol consumption
  • Case-control studies
  • Lymphoma
  • Non-Hodgkin
  • Women

ASJC Scopus subject areas

  • Oncology
  • Epidemiology
  • Cancer Research

Cite this

Morton, L. M., Holford, T. R., Leaderer, B., Zhang, Y., Zahm, S. H., Boyle, P., ... Zheng, T. (2003). Alcohol use and risk of non-Hodgkin's lymphoma among Connecticut women (United States). Cancer Causes and Control, 14(7), 687-694. https://doi.org/10.1023/A:1025626208861

Alcohol use and risk of non-Hodgkin's lymphoma among Connecticut women (United States). / Morton, Lindsay McOmber; Holford, Theodore R.; Leaderer, Brian; Zhang, Yawei; Zahm, Shelia Hoar; Boyle, Peter; Flynn, Stuart D; Tallini, Giovanni; Owens, Patricia H.; Zhang, Bing; Zheng, Tongzhang.

In: Cancer Causes and Control, Vol. 14, No. 7, 09.2003, p. 687-694.

Research output: Contribution to journalArticle

Morton, LM, Holford, TR, Leaderer, B, Zhang, Y, Zahm, SH, Boyle, P, Flynn, SD, Tallini, G, Owens, PH, Zhang, B & Zheng, T 2003, 'Alcohol use and risk of non-Hodgkin's lymphoma among Connecticut women (United States)', Cancer Causes and Control, vol. 14, no. 7, pp. 687-694. https://doi.org/10.1023/A:1025626208861
Morton, Lindsay McOmber ; Holford, Theodore R. ; Leaderer, Brian ; Zhang, Yawei ; Zahm, Shelia Hoar ; Boyle, Peter ; Flynn, Stuart D ; Tallini, Giovanni ; Owens, Patricia H. ; Zhang, Bing ; Zheng, Tongzhang. / Alcohol use and risk of non-Hodgkin's lymphoma among Connecticut women (United States). In: Cancer Causes and Control. 2003 ; Vol. 14, No. 7. pp. 687-694.
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