Aldol reactions in multicomponent reaction based domino pathways: A multipurpose enabling tool in heterocyclic chemistry

Zhigang Xu, Fabio De Moliner, Alexandra P. Cappelli, Christopher Hulme

Research output: Contribution to journalArticlepeer-review

66 Scopus citations

Abstract

The aldol reaction has been evaluated in combination with the Ugi multicomponent reaction to assemble richly decorated mono- and polycyclic systems via expeditious cascade pathways. A small collection of pyrrolinones was generated thereof, and the scarcely accessible pyridoquinoxalinedione scaffold was also prepared by designing an additional nucleophilic substitution step in this domino sequence requiring minimal operational effort.

Original languageEnglish (US)
Pages (from-to)2738-2741
Number of pages4
JournalOrganic Letters
Volume15
Issue number11
DOIs
StatePublished - Jun 7 2013

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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