Aldose reductase-deficient mice develop nephrogenic diabetes insipidus

H. T B Ho, S. K. Chung, J. W S Law, B. C B Ko, S. C F Tam, Heddwen L Brooks, M. A. Knepper, S. S M Chung

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Aldose reductase (ALR2) is thought to be involved in the pathogenesis of various diseases associated with diabetes mellitus, such as cataract, retinopathy, neuropathy, and nephropathy. However, its physiological functions are not well understood. We developed mice deficient in this enzyme and found that they had no apparent developmental or reproductive abnormality except that they drank and urinated significantly more than their wild-type littermates. These ALR2-deficient mice exhibited a partially defective urine-concentrating ability, having a phenotype resembling that of nephrogenic diabetes insipidus.

Original languageEnglish (US)
Pages (from-to)5840-5846
Number of pages7
JournalMolecular and Cellular Biology
Volume20
Issue number16
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Nephrogenic Diabetes Insipidus
Aldehyde Reductase
Kidney Concentrating Ability
Cataract
Diabetes Mellitus
Phenotype
Enzymes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Ho, H. T. B., Chung, S. K., Law, J. W. S., Ko, B. C. B., Tam, S. C. F., Brooks, H. L., ... Chung, S. S. M. (2000). Aldose reductase-deficient mice develop nephrogenic diabetes insipidus. Molecular and Cellular Biology, 20(16), 5840-5846. https://doi.org/10.1128/MCB.20.16.5840-5846.2000

Aldose reductase-deficient mice develop nephrogenic diabetes insipidus. / Ho, H. T B; Chung, S. K.; Law, J. W S; Ko, B. C B; Tam, S. C F; Brooks, Heddwen L; Knepper, M. A.; Chung, S. S M.

In: Molecular and Cellular Biology, Vol. 20, No. 16, 2000, p. 5840-5846.

Research output: Contribution to journalArticle

Ho, HTB, Chung, SK, Law, JWS, Ko, BCB, Tam, SCF, Brooks, HL, Knepper, MA & Chung, SSM 2000, 'Aldose reductase-deficient mice develop nephrogenic diabetes insipidus', Molecular and Cellular Biology, vol. 20, no. 16, pp. 5840-5846. https://doi.org/10.1128/MCB.20.16.5840-5846.2000
Ho, H. T B ; Chung, S. K. ; Law, J. W S ; Ko, B. C B ; Tam, S. C F ; Brooks, Heddwen L ; Knepper, M. A. ; Chung, S. S M. / Aldose reductase-deficient mice develop nephrogenic diabetes insipidus. In: Molecular and Cellular Biology. 2000 ; Vol. 20, No. 16. pp. 5840-5846.
@article{102f5dce27d14f7f86b7c6464c7ebccd,
title = "Aldose reductase-deficient mice develop nephrogenic diabetes insipidus",
abstract = "Aldose reductase (ALR2) is thought to be involved in the pathogenesis of various diseases associated with diabetes mellitus, such as cataract, retinopathy, neuropathy, and nephropathy. However, its physiological functions are not well understood. We developed mice deficient in this enzyme and found that they had no apparent developmental or reproductive abnormality except that they drank and urinated significantly more than their wild-type littermates. These ALR2-deficient mice exhibited a partially defective urine-concentrating ability, having a phenotype resembling that of nephrogenic diabetes insipidus.",
author = "Ho, {H. T B} and Chung, {S. K.} and Law, {J. W S} and Ko, {B. C B} and Tam, {S. C F} and Brooks, {Heddwen L} and Knepper, {M. A.} and Chung, {S. S M}",
year = "2000",
doi = "10.1128/MCB.20.16.5840-5846.2000",
language = "English (US)",
volume = "20",
pages = "5840--5846",
journal = "Molecular and Cellular Biology",
issn = "0270-7306",
publisher = "American Society for Microbiology",
number = "16",

}

TY - JOUR

T1 - Aldose reductase-deficient mice develop nephrogenic diabetes insipidus

AU - Ho, H. T B

AU - Chung, S. K.

AU - Law, J. W S

AU - Ko, B. C B

AU - Tam, S. C F

AU - Brooks, Heddwen L

AU - Knepper, M. A.

AU - Chung, S. S M

PY - 2000

Y1 - 2000

N2 - Aldose reductase (ALR2) is thought to be involved in the pathogenesis of various diseases associated with diabetes mellitus, such as cataract, retinopathy, neuropathy, and nephropathy. However, its physiological functions are not well understood. We developed mice deficient in this enzyme and found that they had no apparent developmental or reproductive abnormality except that they drank and urinated significantly more than their wild-type littermates. These ALR2-deficient mice exhibited a partially defective urine-concentrating ability, having a phenotype resembling that of nephrogenic diabetes insipidus.

AB - Aldose reductase (ALR2) is thought to be involved in the pathogenesis of various diseases associated with diabetes mellitus, such as cataract, retinopathy, neuropathy, and nephropathy. However, its physiological functions are not well understood. We developed mice deficient in this enzyme and found that they had no apparent developmental or reproductive abnormality except that they drank and urinated significantly more than their wild-type littermates. These ALR2-deficient mice exhibited a partially defective urine-concentrating ability, having a phenotype resembling that of nephrogenic diabetes insipidus.

UR - http://www.scopus.com/inward/record.url?scp=0033859766&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033859766&partnerID=8YFLogxK

U2 - 10.1128/MCB.20.16.5840-5846.2000

DO - 10.1128/MCB.20.16.5840-5846.2000

M3 - Article

C2 - 10913167

AN - SCOPUS:0033859766

VL - 20

SP - 5840

EP - 5846

JO - Molecular and Cellular Biology

JF - Molecular and Cellular Biology

SN - 0270-7306

IS - 16

ER -