Aldose reductase-deficient mice develop nephrogenic diabetes insipidus

H. T.B. Ho, S. K. Chung, J. W.S. Law, B. C.B. Ko, S. C.F. Tam, H. L. Brooks, M. A. Knepper, S. S.M. Chung

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83 Scopus citations


Aldose reductase (ALR2) is thought to be involved in the pathogenesis of various diseases associated with diabetes mellitus, such as cataract, retinopathy, neuropathy, and nephropathy. However, its physiological functions are not well understood. We developed mice deficient in this enzyme and found that they had no apparent developmental or reproductive abnormality except that they drank and urinated significantly more than their wild-type littermates. These ALR2-deficient mice exhibited a partially defective urine-concentrating ability, having a phenotype resembling that of nephrogenic diabetes insipidus.

Original languageEnglish (US)
Pages (from-to)5840-5846
Number of pages7
JournalMolecular and cellular biology
Issue number16
StatePublished - Aug 21 2000
Externally publishedYes


ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Ho, H. T. B., Chung, S. K., Law, J. W. S., Ko, B. C. B., Tam, S. C. F., Brooks, H. L., Knepper, M. A., & Chung, S. S. M. (2000). Aldose reductase-deficient mice develop nephrogenic diabetes insipidus. Molecular and cellular biology, 20(16), 5840-5846.