Aldose reductase-deficient mice develop nephrogenic diabetes insipidus

H. T.B. Ho, S. K. Chung, J. W.S. Law, B. C.B. Ko, S. C.F. Tam, H. L. Brooks, M. A. Knepper, S. S.M. Chung

Research output: Contribution to journalArticlepeer-review

83 Scopus citations

Abstract

Aldose reductase (ALR2) is thought to be involved in the pathogenesis of various diseases associated with diabetes mellitus, such as cataract, retinopathy, neuropathy, and nephropathy. However, its physiological functions are not well understood. We developed mice deficient in this enzyme and found that they had no apparent developmental or reproductive abnormality except that they drank and urinated significantly more than their wild-type littermates. These ALR2-deficient mice exhibited a partially defective urine-concentrating ability, having a phenotype resembling that of nephrogenic diabetes insipidus.

Original languageEnglish (US)
Pages (from-to)5840-5846
Number of pages7
JournalMolecular and cellular biology
Volume20
Issue number16
DOIs
StatePublished - 2000

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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