Allelic diversity at the DLA-88 locus in Golden Retriever and Boxer breeds is limited

P. Ross, A. S. Buntzman, B. G. Vincent, E. N. Grover, G. S. Gojanovich, E. J. Collins, J. A. Frelinger, P. R. Hess

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

In the dog, previous analyses of major histocompatibility complex class I genes suggest a single polymorphic locus, dog leukocyte antigen (DLA)-88. While 51 alleles have been reported, estimates of prevalence have not been made. We hypothesized that, within a breed, DLA-88 diversity would be restricted, and one or more dominant alleles could be identified. Accordingly, we determined allele usage in 47 Golden Retrievers and 39 Boxers. In each population, 10 alleles were found; 4 were shared. Seven novel alleles were identified. DLA-88*05101 and *50801 predominated in Golden Retrievers, while most Boxers carried *03401. In these breeds, DLA-88 polymorphisms are limited and largely non-overlapping. The finding of highly prevalent alleles fulfills an important prerequisite for studying canine CD8+ T-cell responses.

Original languageEnglish (US)
Pages (from-to)175-183
Number of pages9
JournalTissue Antigens
Volume80
Issue number2
DOIs
StatePublished - Aug 2012

Keywords

  • Breeds
  • Canine
  • Class I genes
  • Major histocompatibility complex
  • Polymorphisms

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics

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    Ross, P., Buntzman, A. S., Vincent, B. G., Grover, E. N., Gojanovich, G. S., Collins, E. J., Frelinger, J. A., & Hess, P. R. (2012). Allelic diversity at the DLA-88 locus in Golden Retriever and Boxer breeds is limited. Tissue Antigens, 80(2), 175-183. https://doi.org/10.1111/j.1399-0039.2012.01889.x