Allelic loss in ovarian cancer

T. L. Yang-Feng, H. Han, K. C. Chen, S. Li, E. B. Claus, M. L. Carcangiu, Setsuko K Chambers, J. T. Chambers, P. E. Schwartz

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

Loss of heterozygosity (LOH) was examined at 86 loci distributed on every chromosomal arm in 50 human ovarian tumors. Frequent allele losses were observed on chromosomes 13q (42%), 17p (42%), 17q (45%), and Xp (41%). Deletion mapping on chromosome 17 revealed a candidate gene on the long arm distal to D17S41/S74 for ovarian cancer which is distant from the locus for early onset breast cancer. LOH on chromosome 17q was found to be concordant with LOH on chromosomes 3p, 13q, 17p and Xp suggesting that it may be an early event in neoplastic development. These findings indicate that multiple tumor-suppressor genes for ovarian cancer possibly exist on chromosomes 13q, 17, and/or Xp and provide the basis for the identification of candidate gene(s) associated with ovarian cancer. The chromosomal mechanisms resulting in allele losses in ovarian cancer include deletion, deletion/duplication, mitotic recombination and monosomy, in concordance with the developed genetic model.

Original languageEnglish (US)
Pages (from-to)546-551
Number of pages6
JournalInternational Journal of Cancer
Volume54
Issue number4
StatePublished - 1993
Externally publishedYes

Fingerprint

Loss of Heterozygosity
Ovarian Neoplasms
Chromosomes, Human, Pair 17
Chromosomes
Alleles
Monosomy
Genetic Models
Genetic Association Studies
Tumor Suppressor Genes
Genetic Recombination
Breast Neoplasms
Genes
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Yang-Feng, T. L., Han, H., Chen, K. C., Li, S., Claus, E. B., Carcangiu, M. L., ... Schwartz, P. E. (1993). Allelic loss in ovarian cancer. International Journal of Cancer, 54(4), 546-551.

Allelic loss in ovarian cancer. / Yang-Feng, T. L.; Han, H.; Chen, K. C.; Li, S.; Claus, E. B.; Carcangiu, M. L.; Chambers, Setsuko K; Chambers, J. T.; Schwartz, P. E.

In: International Journal of Cancer, Vol. 54, No. 4, 1993, p. 546-551.

Research output: Contribution to journalArticle

Yang-Feng, TL, Han, H, Chen, KC, Li, S, Claus, EB, Carcangiu, ML, Chambers, SK, Chambers, JT & Schwartz, PE 1993, 'Allelic loss in ovarian cancer', International Journal of Cancer, vol. 54, no. 4, pp. 546-551.
Yang-Feng TL, Han H, Chen KC, Li S, Claus EB, Carcangiu ML et al. Allelic loss in ovarian cancer. International Journal of Cancer. 1993;54(4):546-551.
Yang-Feng, T. L. ; Han, H. ; Chen, K. C. ; Li, S. ; Claus, E. B. ; Carcangiu, M. L. ; Chambers, Setsuko K ; Chambers, J. T. ; Schwartz, P. E. / Allelic loss in ovarian cancer. In: International Journal of Cancer. 1993 ; Vol. 54, No. 4. pp. 546-551.
@article{633e9bf56d9843869023a853bcdb2744,
title = "Allelic loss in ovarian cancer",
abstract = "Loss of heterozygosity (LOH) was examined at 86 loci distributed on every chromosomal arm in 50 human ovarian tumors. Frequent allele losses were observed on chromosomes 13q (42{\%}), 17p (42{\%}), 17q (45{\%}), and Xp (41{\%}). Deletion mapping on chromosome 17 revealed a candidate gene on the long arm distal to D17S41/S74 for ovarian cancer which is distant from the locus for early onset breast cancer. LOH on chromosome 17q was found to be concordant with LOH on chromosomes 3p, 13q, 17p and Xp suggesting that it may be an early event in neoplastic development. These findings indicate that multiple tumor-suppressor genes for ovarian cancer possibly exist on chromosomes 13q, 17, and/or Xp and provide the basis for the identification of candidate gene(s) associated with ovarian cancer. The chromosomal mechanisms resulting in allele losses in ovarian cancer include deletion, deletion/duplication, mitotic recombination and monosomy, in concordance with the developed genetic model.",
author = "Yang-Feng, {T. L.} and H. Han and Chen, {K. C.} and S. Li and Claus, {E. B.} and Carcangiu, {M. L.} and Chambers, {Setsuko K} and Chambers, {J. T.} and Schwartz, {P. E.}",
year = "1993",
language = "English (US)",
volume = "54",
pages = "546--551",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - Allelic loss in ovarian cancer

AU - Yang-Feng, T. L.

AU - Han, H.

AU - Chen, K. C.

AU - Li, S.

AU - Claus, E. B.

AU - Carcangiu, M. L.

AU - Chambers, Setsuko K

AU - Chambers, J. T.

AU - Schwartz, P. E.

PY - 1993

Y1 - 1993

N2 - Loss of heterozygosity (LOH) was examined at 86 loci distributed on every chromosomal arm in 50 human ovarian tumors. Frequent allele losses were observed on chromosomes 13q (42%), 17p (42%), 17q (45%), and Xp (41%). Deletion mapping on chromosome 17 revealed a candidate gene on the long arm distal to D17S41/S74 for ovarian cancer which is distant from the locus for early onset breast cancer. LOH on chromosome 17q was found to be concordant with LOH on chromosomes 3p, 13q, 17p and Xp suggesting that it may be an early event in neoplastic development. These findings indicate that multiple tumor-suppressor genes for ovarian cancer possibly exist on chromosomes 13q, 17, and/or Xp and provide the basis for the identification of candidate gene(s) associated with ovarian cancer. The chromosomal mechanisms resulting in allele losses in ovarian cancer include deletion, deletion/duplication, mitotic recombination and monosomy, in concordance with the developed genetic model.

AB - Loss of heterozygosity (LOH) was examined at 86 loci distributed on every chromosomal arm in 50 human ovarian tumors. Frequent allele losses were observed on chromosomes 13q (42%), 17p (42%), 17q (45%), and Xp (41%). Deletion mapping on chromosome 17 revealed a candidate gene on the long arm distal to D17S41/S74 for ovarian cancer which is distant from the locus for early onset breast cancer. LOH on chromosome 17q was found to be concordant with LOH on chromosomes 3p, 13q, 17p and Xp suggesting that it may be an early event in neoplastic development. These findings indicate that multiple tumor-suppressor genes for ovarian cancer possibly exist on chromosomes 13q, 17, and/or Xp and provide the basis for the identification of candidate gene(s) associated with ovarian cancer. The chromosomal mechanisms resulting in allele losses in ovarian cancer include deletion, deletion/duplication, mitotic recombination and monosomy, in concordance with the developed genetic model.

UR - http://www.scopus.com/inward/record.url?scp=0027269846&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027269846&partnerID=8YFLogxK

M3 - Article

VL - 54

SP - 546

EP - 551

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 4

ER -