Allopurinol-hypersensitivity vasculitis and liver damage

Thomas D Boyer, N. Sun, T. B. Reynolds

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Fever, skin rash, renal failure and liver disease developed in 3 patients 3 to 4 wk after treatment with allopurinol was begun. Two of the patients recovered following therapy with corticosteroids. After recovery from the initial illness, allopurinol was readministered to one patient and fever and skin rash recurred. Allopurinol hypersensitivity should be included in the differential diagnosis of hepatocellular necrosis and renal failure. Early diagnosis is essential because the continued administration of allopurinol may result in a protracted illness and increased mortality.

Original languageEnglish (US)
Pages (from-to)143-147
Number of pages5
JournalWestern Journal of Medicine
Volume126
Issue number2
StatePublished - 1977
Externally publishedYes

Fingerprint

Cutaneous Leukocytoclastic Vasculitis
Allopurinol
Liver
Exanthema
Renal Insufficiency
Fever
Liver Diseases
Early Diagnosis
Adrenal Cortex Hormones
Hypersensitivity
Differential Diagnosis
Necrosis
Mortality
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Allopurinol-hypersensitivity vasculitis and liver damage. / Boyer, Thomas D; Sun, N.; Reynolds, T. B.

In: Western Journal of Medicine, Vol. 126, No. 2, 1977, p. 143-147.

Research output: Contribution to journalArticle

Boyer, TD, Sun, N & Reynolds, TB 1977, 'Allopurinol-hypersensitivity vasculitis and liver damage', Western Journal of Medicine, vol. 126, no. 2, pp. 143-147.
Boyer, Thomas D ; Sun, N. ; Reynolds, T. B. / Allopurinol-hypersensitivity vasculitis and liver damage. In: Western Journal of Medicine. 1977 ; Vol. 126, No. 2. pp. 143-147.
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