Alpha-1 adrenergic control of the venous circulation in intact dogs

C. Appleton, M. Olajos, E. Morkin, Steven Goldman

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

To study alpha adrenergic control of the venous circulation, 17 dogs were lightly sedated and instrumented with thermodilution pulmonary flow and aortic catheters. Hemodynamics, cardiac output and central blood volume were measured at rest. Mean circulatory filling pressure, pressure gradient for venous return and resistance to venous return were calculated from pressures obtained during transient acetylcholine-induced circulatory arrest. Phenylephrine was then infused at two steady-state levels to increase mean aortic pressures by 50 and 100% above control values. Heart rate was controlled with atropine. Phenylephrine increased (P < .025) mean aortic pressure from 80.7 ± 2.9 to 121.3 ± 7.6 to 164.7 ± 6.1 mm Hg and systemic vascular resistance from 23.3 ± 2.0 to 32.2 ± 3.5 to 43.5 ± 4.1 mm Hg/min/ml and did not change cardiac output (161.9 ± 12.6 - 175.6 ± 13.8 - 169.6 ± 11.9 ml/min/kg). Mean circulatory filling pressure increased from 7.1 ± 0.5 to 9.7 ± 0.6 to 13.2 ± 1.3 mm Hg (P < .025). Pressure gradient for venous return increased from 6.4 ± 0.4 to 7.7 ± 0.4 to 8.9 ± 0.4 mm Hg (P < .025). Central blood volume increased from 16.2 ± 0.9 to 19.4 ± 1.4 to 22.0 ± 1.9 ml/kg (P < .025). To eliminate reflex changes in vascular tone, eight dogs received ganglionic blockade with trimethaphan. After ganglionic blockade phenylephrine increased cardiac output, systemic vascular resistance, mean circulatory filling pressure, pressure gradient for venous return and central blood volume (P < .025). Thus, in conscious dogs, phenylephrine reduces peripheral vascular capacitance and shifts blood from the venous circulation to the central and arterial vascular compartments.

Original languageEnglish (US)
Pages (from-to)729-734
Number of pages6
JournalJournal of Pharmacology and Experimental Therapeutics
Volume233
Issue number3
StatePublished - 1985
Externally publishedYes

Fingerprint

Phenylephrine
Adrenergic Agents
Venous Pressure
Blood Volume
Cardiac Output
Dogs
Pressure
Vascular Resistance
Blood Vessels
Vascular Capacitance
Arterial Pressure
Trimethaphan
Thermodilution
Blood Circulation
Atropine
Acetylcholine
Reflex
Catheters
Heart Rate
Hemodynamics

ASJC Scopus subject areas

  • Pharmacology

Cite this

Alpha-1 adrenergic control of the venous circulation in intact dogs. / Appleton, C.; Olajos, M.; Morkin, E.; Goldman, Steven.

In: Journal of Pharmacology and Experimental Therapeutics, Vol. 233, No. 3, 1985, p. 729-734.

Research output: Contribution to journalArticle

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