Alpha interferon for induction of remission in hairy-cell leukemia

J. R. Quesada, J. Reuben, J. T. Manning, Evan M Hersh, J. U. Gutterman

Research output: Contribution to journalArticle

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Abstract

We treated seven patients who had progressive hairy-cell leukemia with daily doses of 3 million units of partially pure alpha (leukocyte) interferon by the intramuscular route. Three patients had a complete remission, and four had a partial remission, according to strict criteria for a response. After treatment, bone-marrow aspirates showed an absence of leukemia cells in three patients and 5 per cent or fewer in three others. Normalization of subnormal peripheral-blood values occurred in six of six patients with anemia, in seven with granulocytopenia, and in four of four with thrombocytopenia. Remissions have been maintained for over 6 to 10 months. Alpha interferon appears to be highly effective in patients with hairy-cell leukemia.

Original languageEnglish (US)
Pages (from-to)15-18
Number of pages4
JournalNew England Journal of Medicine
Volume310
Issue number1
StatePublished - 1984
Externally publishedYes

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Remission Induction
Hairy Cell Leukemia
Interferon-alpha
Agranulocytosis
Thrombocytopenia
Anemia
Leukemia
Bone Marrow

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Quesada, J. R., Reuben, J., Manning, J. T., Hersh, E. M., & Gutterman, J. U. (1984). Alpha interferon for induction of remission in hairy-cell leukemia. New England Journal of Medicine, 310(1), 15-18.

Alpha interferon for induction of remission in hairy-cell leukemia. / Quesada, J. R.; Reuben, J.; Manning, J. T.; Hersh, Evan M; Gutterman, J. U.

In: New England Journal of Medicine, Vol. 310, No. 1, 1984, p. 15-18.

Research output: Contribution to journalArticle

Quesada, JR, Reuben, J, Manning, JT, Hersh, EM & Gutterman, JU 1984, 'Alpha interferon for induction of remission in hairy-cell leukemia', New England Journal of Medicine, vol. 310, no. 1, pp. 15-18.
Quesada, J. R. ; Reuben, J. ; Manning, J. T. ; Hersh, Evan M ; Gutterman, J. U. / Alpha interferon for induction of remission in hairy-cell leukemia. In: New England Journal of Medicine. 1984 ; Vol. 310, No. 1. pp. 15-18.
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