Alteration of cell-mediated immunity to Listeria monocytogenes in protein-malnourished mice treated with thymosin fraction V

T. M. Petro, G. Chien, Ronald R Watson

Research output: Contribution to journalArticle

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Abstract

Cell-mediated immune reactivity, measured by lymphocyte responsiveness to phytohemagglutinin, was higher in both young or aged mice fed a 4% casein diet compared with age-matched controls. Treatment in vivo with bovine thymosin fraction V decreased the responsiveness to phytohemagglutinin of lymphocytes from mice fed either the control or moderately protein-deficient diets when compared with mice treated in vivo with saline. Resistance against Listeria monocytogenes, known to be a cell-mediated immune function, was impaired in young and aged mice which were fed the low-protein diet. Treatment with thymosin was able to significantly improve the cell-mediated immune resistance to L. monocytogenes of moderately protein-malnourished mice. Thymosin treatment impaired the resistance to L. monocytogenes of young or aged mice fed the control diet. The splenic natural killer cell cytotoxicity of protein-malnourished mice was impaired compared with that of mice fed the control diet. Treatment with thymosin did not restore the natural killer cell cytotoxic activity in protein-malnourished mice, but did enhance the activity in control mice.

Original languageEnglish (US)
Pages (from-to)601-608
Number of pages8
JournalInfection and Immunity
Volume37
Issue number2
StatePublished - 1982
Externally publishedYes

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Listeria monocytogenes
Cellular Immunity
Thymosin
Proteins
Diet
Phytohemagglutinins
Natural Killer Cells
Lymphocytes
thymosin fraction 5
Protein-Restricted Diet
Therapeutics
Caseins

ASJC Scopus subject areas

  • Immunology

Cite this

Alteration of cell-mediated immunity to Listeria monocytogenes in protein-malnourished mice treated with thymosin fraction V. / Petro, T. M.; Chien, G.; Watson, Ronald R.

In: Infection and Immunity, Vol. 37, No. 2, 1982, p. 601-608.

Research output: Contribution to journalArticle

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