Alterations in central and peripheral adrenergic receptors in deoxycorticosterone/salt hypertensive rats

Shizuo Yamada, Henry I. Yamamura, William R Roeske

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

The treatment of uninephrectomized rats with deoxycorticosterone (DOCA) and salt for 6 weeks caused a significant systolic hypertension and cardiac and renal hypertrophy. There was a significant decrease in the density of cardiac α1- and β-, and renal α1-adrenoceptors in DOCA/salt hypertensive rats, as compared to uninephrectomized salt loaded control rats. In contrast, the cerebral cortex, corpus striatum, hippocampus and hypothalamus/thalamus of hypertensive rats showed a significant increase in adrenoceptor binding in these hypertensive rats. In contrast, muscarinic cholinergic receptors and [3H]yohimbine binding sites were not altered in most tissues of the hypertensive rats. The present study suggests an important role for central and peripheral α1- and β-adrenoceptors in the pathogenesis of hypertension.

Original languageEnglish (US)
Pages (from-to)2405-2416
Number of pages12
JournalLife Sciences
Volume27
Issue number24
DOIs
StatePublished - Dec 15 1980

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Desoxycorticosterone
Adrenergic Receptors
Rats
Salts
Desoxycorticosterone Acetate
Rat control
Yohimbine
Corpus Striatum
Cholinergic Receptors
Renal Hypertension
Cholinergic Agents
Cardiomegaly
Muscarinic Receptors
Thalamus
Cerebral Cortex
Hypothalamus
Binding Sites
Hippocampus
Tissue
Hypertension

ASJC Scopus subject areas

  • Pharmacology

Cite this

Alterations in central and peripheral adrenergic receptors in deoxycorticosterone/salt hypertensive rats. / Yamada, Shizuo; Yamamura, Henry I.; Roeske, William R.

In: Life Sciences, Vol. 27, No. 24, 15.12.1980, p. 2405-2416.

Research output: Contribution to journalArticle

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