Alterations in central and peripheral adrenergic receptors in deoxycorticosterone/salt hypertensive rats

Shizuo Yamada, Henry I. Yamamura, William R. Roeske

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

The treatment of uninephrectomized rats with deoxycorticosterone (DOCA) and salt for 6 weeks caused a significant systolic hypertension and cardiac and renal hypertrophy. There was a significant decrease in the density of cardiac α1- and β-, and renal α1-adrenoceptors in DOCA/salt hypertensive rats, as compared to uninephrectomized salt loaded control rats. In contrast, the cerebral cortex, corpus striatum, hippocampus and hypothalamus/thalamus of hypertensive rats showed a significant increase in adrenoceptor binding in these hypertensive rats. In contrast, muscarinic cholinergic receptors and [3H]yohimbine binding sites were not altered in most tissues of the hypertensive rats. The present study suggests an important role for central and peripheral α1- and β-adrenoceptors in the pathogenesis of hypertension.

Original languageEnglish (US)
Pages (from-to)2405-2416
Number of pages12
JournalLife Sciences
Volume27
Issue number24
DOIs
StatePublished - Dec 15 1980

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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