Abstract
Transforming growth factors β (TGF-βs) are peptides involved in autocrine and paracrine control of cell growth and differentiation. In the kidneys, TGF-β2 has been shown to localize specifically in renin-producing cells in various conditions stimulating the renin response. To test in vivo the functional role of TGF-β2, the renin response was investigated in mice heterozygous for a null mutation of the TGF-β2 gene, which had a two-fold reduction in the amount of TGF-β2 mRNA. Although the increase in plasma renin concentration triggered by dehydration was not different from wild-type mice, renal renin mRNA and protein levels were higher in mutant mice under hydrated or dehydrated conditions. These data suggest that TGF-β2 exerts an inhibitory effect on renin synthesis and release from the juxtaglomerular apparatuses. Copyright
| Original language | English (US) |
|---|---|
| Pages (from-to) | 374-382 |
| Number of pages | 9 |
| Journal | Experimental Nephrology |
| Volume | 10 |
| Issue number | 5-6 |
| DOIs | |
| State | Published - 2002 |
| Externally published | Yes |
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Keywords
- Heterozygous deficient mice
- Kidneys
- Renin synthesis and secretion
- Transforming growth factor-β
ASJC Scopus subject areas
- Nephrology
Cite this
Altered renin synthesis and secretion in the kidneys of heterozygous mice with a null mutation in the TGF-β2 gene. / Pietri, Laurence; Bloch-Faure, May; Belair, Marie France; Sanford, L. Philip; Doetschman, Thomas C; Ménard, Joël; Bruneval, Patrick; Meneton, Pierre.
In: Experimental Nephrology, Vol. 10, No. 5-6, 2002, p. 374-382.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Altered renin synthesis and secretion in the kidneys of heterozygous mice with a null mutation in the TGF-β2 gene
AU - Pietri, Laurence
AU - Bloch-Faure, May
AU - Belair, Marie France
AU - Sanford, L. Philip
AU - Doetschman, Thomas C
AU - Ménard, Joël
AU - Bruneval, Patrick
AU - Meneton, Pierre
PY - 2002
Y1 - 2002
N2 - Transforming growth factors β (TGF-βs) are peptides involved in autocrine and paracrine control of cell growth and differentiation. In the kidneys, TGF-β2 has been shown to localize specifically in renin-producing cells in various conditions stimulating the renin response. To test in vivo the functional role of TGF-β2, the renin response was investigated in mice heterozygous for a null mutation of the TGF-β2 gene, which had a two-fold reduction in the amount of TGF-β2 mRNA. Although the increase in plasma renin concentration triggered by dehydration was not different from wild-type mice, renal renin mRNA and protein levels were higher in mutant mice under hydrated or dehydrated conditions. These data suggest that TGF-β2 exerts an inhibitory effect on renin synthesis and release from the juxtaglomerular apparatuses. Copyright
AB - Transforming growth factors β (TGF-βs) are peptides involved in autocrine and paracrine control of cell growth and differentiation. In the kidneys, TGF-β2 has been shown to localize specifically in renin-producing cells in various conditions stimulating the renin response. To test in vivo the functional role of TGF-β2, the renin response was investigated in mice heterozygous for a null mutation of the TGF-β2 gene, which had a two-fold reduction in the amount of TGF-β2 mRNA. Although the increase in plasma renin concentration triggered by dehydration was not different from wild-type mice, renal renin mRNA and protein levels were higher in mutant mice under hydrated or dehydrated conditions. These data suggest that TGF-β2 exerts an inhibitory effect on renin synthesis and release from the juxtaglomerular apparatuses. Copyright
KW - Heterozygous deficient mice
KW - Kidneys
KW - Renin synthesis and secretion
KW - Transforming growth factor-β
UR - http://www.scopus.com/inward/record.url?scp=0036966712&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036966712&partnerID=8YFLogxK
U2 - 10.1159/000065302
DO - 10.1159/000065302
M3 - Article
C2 - 12381922
AN - SCOPUS:0036966712
VL - 10
SP - 374
EP - 382
JO - Experimental Nephrology
JF - Experimental Nephrology
SN - 0028-2766
IS - 5-6
ER -