Altered renin synthesis and secretion in the kidneys of heterozygous mice with a null mutation in the TGF-β2 gene

Laurence Pietri, May Bloch-Faure, Marie France Belair, L. Philip Sanford, Tom Doetschman, Joël Ménard, Patrick Bruneval, Pierre Meneton

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Transforming growth factors β (TGF-βs) are peptides involved in autocrine and paracrine control of cell growth and differentiation. In the kidneys, TGF-β2 has been shown to localize specifically in renin-producing cells in various conditions stimulating the renin response. To test in vivo the functional role of TGF-β2, the renin response was investigated in mice heterozygous for a null mutation of the TGF-β2 gene, which had a two-fold reduction in the amount of TGF-β2 mRNA. Although the increase in plasma renin concentration triggered by dehydration was not different from wild-type mice, renal renin mRNA and protein levels were higher in mutant mice under hydrated or dehydrated conditions. These data suggest that TGF-β2 exerts an inhibitory effect on renin synthesis and release from the juxtaglomerular apparatuses. Copyright

Original languageEnglish (US)
Pages (from-to)374-382
Number of pages9
JournalExperimental Nephrology
Volume10
Issue number5-6
DOIs
StatePublished - Dec 1 2002
Externally publishedYes

Keywords

  • Heterozygous deficient mice
  • Kidneys
  • Renin synthesis and secretion
  • Transforming growth factor-β

ASJC Scopus subject areas

  • Nephrology

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    Pietri, L., Bloch-Faure, M., Belair, M. F., Sanford, L. P., Doetschman, T., Ménard, J., Bruneval, P., & Meneton, P. (2002). Altered renin synthesis and secretion in the kidneys of heterozygous mice with a null mutation in the TGF-β2 gene. Experimental Nephrology, 10(5-6), 374-382. https://doi.org/10.1159/000065302