Altered renin synthesis and secretion in the kidneys of heterozygous mice with a null mutation in the TGF-β2 gene

Laurence Pietri, May Bloch-Faure, Marie France Belair, L. Philip Sanford, Thomas C Doetschman, Joël Ménard, Patrick Bruneval, Pierre Meneton

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Transforming growth factors β (TGF-βs) are peptides involved in autocrine and paracrine control of cell growth and differentiation. In the kidneys, TGF-β2 has been shown to localize specifically in renin-producing cells in various conditions stimulating the renin response. To test in vivo the functional role of TGF-β2, the renin response was investigated in mice heterozygous for a null mutation of the TGF-β2 gene, which had a two-fold reduction in the amount of TGF-β2 mRNA. Although the increase in plasma renin concentration triggered by dehydration was not different from wild-type mice, renal renin mRNA and protein levels were higher in mutant mice under hydrated or dehydrated conditions. These data suggest that TGF-β2 exerts an inhibitory effect on renin synthesis and release from the juxtaglomerular apparatuses. Copyright

Original languageEnglish (US)
Pages (from-to)374-382
Number of pages9
JournalExperimental Nephrology
Volume10
Issue number5-6
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Renin
Kidney
Mutation
Genes
Juxtaglomerular Apparatus
Messenger RNA
Transforming Growth Factors
Dehydration
Cell Differentiation
Peptides
Growth
Proteins

Keywords

  • Heterozygous deficient mice
  • Kidneys
  • Renin synthesis and secretion
  • Transforming growth factor-β

ASJC Scopus subject areas

  • Nephrology

Cite this

Altered renin synthesis and secretion in the kidneys of heterozygous mice with a null mutation in the TGF-β2 gene. / Pietri, Laurence; Bloch-Faure, May; Belair, Marie France; Sanford, L. Philip; Doetschman, Thomas C; Ménard, Joël; Bruneval, Patrick; Meneton, Pierre.

In: Experimental Nephrology, Vol. 10, No. 5-6, 2002, p. 374-382.

Research output: Contribution to journalArticle

Pietri, L, Bloch-Faure, M, Belair, MF, Sanford, LP, Doetschman, TC, Ménard, J, Bruneval, P & Meneton, P 2002, 'Altered renin synthesis and secretion in the kidneys of heterozygous mice with a null mutation in the TGF-β2 gene', Experimental Nephrology, vol. 10, no. 5-6, pp. 374-382. https://doi.org/10.1159/000065302
Pietri, Laurence ; Bloch-Faure, May ; Belair, Marie France ; Sanford, L. Philip ; Doetschman, Thomas C ; Ménard, Joël ; Bruneval, Patrick ; Meneton, Pierre. / Altered renin synthesis and secretion in the kidneys of heterozygous mice with a null mutation in the TGF-β2 gene. In: Experimental Nephrology. 2002 ; Vol. 10, No. 5-6. pp. 374-382.
@article{2c5a8843597f4404ae3315740d5df471,
title = "Altered renin synthesis and secretion in the kidneys of heterozygous mice with a null mutation in the TGF-β2 gene",
abstract = "Transforming growth factors β (TGF-βs) are peptides involved in autocrine and paracrine control of cell growth and differentiation. In the kidneys, TGF-β2 has been shown to localize specifically in renin-producing cells in various conditions stimulating the renin response. To test in vivo the functional role of TGF-β2, the renin response was investigated in mice heterozygous for a null mutation of the TGF-β2 gene, which had a two-fold reduction in the amount of TGF-β2 mRNA. Although the increase in plasma renin concentration triggered by dehydration was not different from wild-type mice, renal renin mRNA and protein levels were higher in mutant mice under hydrated or dehydrated conditions. These data suggest that TGF-β2 exerts an inhibitory effect on renin synthesis and release from the juxtaglomerular apparatuses. Copyright",
keywords = "Heterozygous deficient mice, Kidneys, Renin synthesis and secretion, Transforming growth factor-β",
author = "Laurence Pietri and May Bloch-Faure and Belair, {Marie France} and Sanford, {L. Philip} and Doetschman, {Thomas C} and Jo{\"e}l M{\'e}nard and Patrick Bruneval and Pierre Meneton",
year = "2002",
doi = "10.1159/000065302",
language = "English (US)",
volume = "10",
pages = "374--382",
journal = "Experimental Nephrology",
issn = "0028-2766",
publisher = "S. Karger AG",
number = "5-6",

}

TY - JOUR

T1 - Altered renin synthesis and secretion in the kidneys of heterozygous mice with a null mutation in the TGF-β2 gene

AU - Pietri, Laurence

AU - Bloch-Faure, May

AU - Belair, Marie France

AU - Sanford, L. Philip

AU - Doetschman, Thomas C

AU - Ménard, Joël

AU - Bruneval, Patrick

AU - Meneton, Pierre

PY - 2002

Y1 - 2002

N2 - Transforming growth factors β (TGF-βs) are peptides involved in autocrine and paracrine control of cell growth and differentiation. In the kidneys, TGF-β2 has been shown to localize specifically in renin-producing cells in various conditions stimulating the renin response. To test in vivo the functional role of TGF-β2, the renin response was investigated in mice heterozygous for a null mutation of the TGF-β2 gene, which had a two-fold reduction in the amount of TGF-β2 mRNA. Although the increase in plasma renin concentration triggered by dehydration was not different from wild-type mice, renal renin mRNA and protein levels were higher in mutant mice under hydrated or dehydrated conditions. These data suggest that TGF-β2 exerts an inhibitory effect on renin synthesis and release from the juxtaglomerular apparatuses. Copyright

AB - Transforming growth factors β (TGF-βs) are peptides involved in autocrine and paracrine control of cell growth and differentiation. In the kidneys, TGF-β2 has been shown to localize specifically in renin-producing cells in various conditions stimulating the renin response. To test in vivo the functional role of TGF-β2, the renin response was investigated in mice heterozygous for a null mutation of the TGF-β2 gene, which had a two-fold reduction in the amount of TGF-β2 mRNA. Although the increase in plasma renin concentration triggered by dehydration was not different from wild-type mice, renal renin mRNA and protein levels were higher in mutant mice under hydrated or dehydrated conditions. These data suggest that TGF-β2 exerts an inhibitory effect on renin synthesis and release from the juxtaglomerular apparatuses. Copyright

KW - Heterozygous deficient mice

KW - Kidneys

KW - Renin synthesis and secretion

KW - Transforming growth factor-β

UR - http://www.scopus.com/inward/record.url?scp=0036966712&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036966712&partnerID=8YFLogxK

U2 - 10.1159/000065302

DO - 10.1159/000065302

M3 - Article

C2 - 12381922

AN - SCOPUS:0036966712

VL - 10

SP - 374

EP - 382

JO - Experimental Nephrology

JF - Experimental Nephrology

SN - 0028-2766

IS - 5-6

ER -