Altering the orientation of proteins on self-assembled monolayers: A computational study

Bartosz Trzaskowski, Filip Leonarski, Andrzej Leś, Ludwik Adamowicz

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

A combined computational docking - molecular dynamics study has been performed on a system consisting of cytochrome c protein and alkanethiol self-assembled monolayers of various geometries. The results suggest that the orientation of the protein on the surface may be controlled or altered by means of designing specific structural motifs on the surface. The proposed computational approach may be used as a fast and reliable tool to complement other theoretical and experimental techniques of exploring other protein - surface interfaces.

Original languageEnglish (US)
Pages (from-to)3239-3245
Number of pages7
JournalBiomacromolecules
Volume9
Issue number11
DOIs
StatePublished - Nov 1 2008

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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