Alternaria sensitisation at age 6 years is associated with subsequent airway hyper-responsiveness in non-asthmatics

Anunya Hiranrattana, Debra A. Stern, Stefano Guerra, Marilyn Halonen, Anne L. Wright, Michael Daines, Fernando D. Martinez, Wayne J. Morgan

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

In the non-selected birth cohort Tucson Children's Respiratory Study, early sensitisation to Alternaria was associated with increased airway hyper-responsiveness (AHR) into adult life among non-asthmatics. The increase in AHR was of a similar magnitude to that seen for Alternaria sensitised asthmatics and was primarily evident among those who were overweight or obese. In contrast, there was no significant association between early sensitisation to aeroallergens other than Alternaria and AHR among non-asthmatics. Why this group of Alternaria sensitised individuals without asthma demonstrated increased AHR of a magnitude similar to asthmatics is unknown and requires further investigation.

Original languageEnglish (US)
JournalThorax
DOIs
StateAccepted/In press - Mar 21 2018

Keywords

  • allergic lung disease
  • asthma
  • asthma epidemiology

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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