Alternative model for Neisseria gonorrhoeae pilin variation

H. S. Seifert, Richard Ajioka, So Magdalene

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The pilus of Neisseria gonorrhoeae, a dominant outer membrane organelle, is a major virulence factor. The pilus undergoes phase variation and antigenic variation has also been observed, both in vitro and in vivo. The current model of pilus variation invokes a gene conversion type recombination between a silent pilin locus and the pilin expression site. Experimental results which led to the creation of this hypothesis are reviewed and data are presented which support an alternative model based on DNA transformation.

Original languageEnglish (US)
Pages (from-to)107-109
Number of pages3
JournalVaccine
Volume6
Issue number2
DOIs
StatePublished - Apr 1988
Externally publishedYes

Keywords

  • Neisseria gonorrhoeae

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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