Alternative model for Neisseria gonorrhoeae pilin variation

H. S. Seifert, Richard Ajioka, Magdalene "Maggie" So

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The pilus of Neisseria gonorrhoeae, a dominant outer membrane organelle, is a major virulence factor. The pilus undergoes phase variation and antigenic variation has also been observed, both in vitro and in vivo. The current model of pilus variation invokes a gene conversion type recombination between a silent pilin locus and the pilin expression site. Experimental results which led to the creation of this hypothesis are reviewed and data are presented which support an alternative model based on DNA transformation.

Original languageEnglish (US)
Pages (from-to)107-109
Number of pages3
JournalVaccine
Volume6
Issue number2
DOIs
StatePublished - 1988
Externally publishedYes

Fingerprint

Neisseria gonorrhoeae
Fimbriae Proteins
fimbriae
Antigenic Variation
Gene Conversion
Virulence Factors
Organelles
Genetic Recombination
antigenic variation
gene conversion
Membranes
organelles
DNA
virulence
loci

Keywords

  • Neisseria gonorrhoeae

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

Alternative model for Neisseria gonorrhoeae pilin variation. / Seifert, H. S.; Ajioka, Richard; So, Magdalene "Maggie".

In: Vaccine, Vol. 6, No. 2, 1988, p. 107-109.

Research output: Contribution to journalArticle

Seifert, H. S. ; Ajioka, Richard ; So, Magdalene "Maggie". / Alternative model for Neisseria gonorrhoeae pilin variation. In: Vaccine. 1988 ; Vol. 6, No. 2. pp. 107-109.
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