Alzheimer's associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia

Thuy Vi V. Nguyen, Megan Hayes, Jacob C. Zbesko, Jennifer B. Frye, Nicole R. Congrove, Nadia P. Belichenko, Brian S Mckay, Frank M. Longo, Kristian Doyle

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The goal of this study was to determine the chronic impact of stroke on the manifestation of Alzheimer's disease (AD) related pathology and behavioral impairments in mice. To accomplish this goal, we used two distinct models. First, we experimentally induced ischemic stroke in aged wildtype (wt) C57BL/6 mice to determine if stroke leads to the manifestation of AD-associated pathological β-amyloid (Aβ) and tau in aged versus young adult wt mice. Second, we utilized a transgenic (Tg) mouse model of AD (hAPP-SL) to determine if stroke leads to the worsening of pre-existing AD pathology, as well as the development of pathology in brain regions not typically expressed in AD Tg mice. In the wt mice, there was delayed motor recovery and an accelerated development of cognitive deficits in aged mice compared to young adult mice following stroke. This corresponded with increased brain atrophy, increased cholinergic degeneration, and a focal increase of Aβ in areas of axonal degeneration in the ipsilateral hemisphere of the aged animals. By contrast, in the hAPP-SL mice, we found that ischemia induced aggravated behavioral deficits in conjunction with a global increase in Aβ, tau, and cholinergic pathology compared to hAPP-SL mice that underwent a sham stroke procedure. With regard to a potential mechanism, in both models, we found that the stroke-induced Aβ and tau deposits co-localized with increased levels of β-secretase 1 (BACE1), along with its substrate, neuregulin 1 (NGR1) type III, both of which are proteins integral for myelin repair. Based on these findings, we propose that the chronic sequelae of stroke may be ratcheting-up a myelin repair pathway, and that the consequent increase in BACE1 could be causing an inadvertent cleavage of its alternative substrate, AβPP, resulting in greater Aβ seeding and pathogenesis.

Original languageEnglish (US)
Number of pages1
JournalActa neuropathologica communications
Volume6
Issue number1
DOIs
StatePublished - Sep 24 2018

Fingerprint

Myelin Sheath
Amyloid
Dementia
Stroke
Alzheimer Disease
Pathology
Cholinergic Agents
Transgenic Mice
Young Adult
Neuregulin-1
Myelin Proteins
Amyloid Precursor Protein Secretases
Preexisting Condition Coverage
Brain
Inbred C57BL Mouse
Atrophy
Ischemia

Keywords

  • Alzheimer’s disease
  • Amyloid
  • BACE1
  • Mixed dementia
  • Myelin repair
  • Neuregulin
  • Stroke
  • Tau

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Alzheimer's associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia. / Nguyen, Thuy Vi V.; Hayes, Megan; Zbesko, Jacob C.; Frye, Jennifer B.; Congrove, Nicole R.; Belichenko, Nadia P.; Mckay, Brian S; Longo, Frank M.; Doyle, Kristian.

In: Acta neuropathologica communications, Vol. 6, No. 1, 24.09.2018.

Research output: Contribution to journalArticle

Nguyen, Thuy Vi V. ; Hayes, Megan ; Zbesko, Jacob C. ; Frye, Jennifer B. ; Congrove, Nicole R. ; Belichenko, Nadia P. ; Mckay, Brian S ; Longo, Frank M. ; Doyle, Kristian. / Alzheimer's associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia. In: Acta neuropathologica communications. 2018 ; Vol. 6, No. 1.
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AU - Hayes, Megan

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AU - Frye, Jennifer B.

AU - Congrove, Nicole R.

AU - Belichenko, Nadia P.

AU - Mckay, Brian S

AU - Longo, Frank M.

AU - Doyle, Kristian

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