AM630 is a competitive cannabinoid receptor antagonist in the guinea pig brain

Keiko Hosohata, Raymond M. Quock, Yoshiaki Hosohata, Thomas H. Burkey, Alexandros Makriyannis, Paul Consroe, William R. Roeske, Henry I. Yamamura

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

AM630 has been demonstrated to be a cannabinoid receptor antagonist in the mouse brain and vas deferens. Conversely, it was recently reported that AM630 acts as a cannabinoid agonist in the guinea pig ileum. This research was designed to determine whether the difference in the action of AM630 is species Studies conducted in guinea pig brain reveal that AM630 antagonizes the stimulatory effect of the cannabinoid agonist WIN 55,212-2 on [35S]GTPγS binding suggesting that difference in AM630 activity in different tissues is not due to species variation.

Original languageEnglish (US)
Pages (from-to)PL115-PL118
JournalLife Sciences
Volume61
Issue number9
DOIs
StatePublished - Jul 25 1997

Keywords

  • Cannabinoid antagonist
  • Guinea pig
  • [S]GTPγS binding

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Hosohata, K., Quock, R. M., Hosohata, Y., Burkey, T. H., Makriyannis, A., Consroe, P., Roeske, W. R., & Yamamura, H. I. (1997). AM630 is a competitive cannabinoid receptor antagonist in the guinea pig brain. Life Sciences, 61(9), PL115-PL118. https://doi.org/10.1016/S0024-3205(97)00596-1