AM630 is a competitive cannabinoid receptor antagonist in the guinea pig brain

Keiko Hosohata, Raymond M. Quock, Yoshiaki Hosohata, Thomas H. Burkey, Alexandros Makriyannis, Paul Consroe, William R Roeske, Henry I. Yamamura

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

AM630 has been demonstrated to be a cannabinoid receptor antagonist in the mouse brain and vas deferens. Conversely, it was recently reported that AM630 acts as a cannabinoid agonist in the guinea pig ileum. This research was designed to determine whether the difference in the action of AM630 is species Studies conducted in guinea pig brain reveal that AM630 antagonizes the stimulatory effect of the cannabinoid agonist WIN 55,212-2 on [35S]GTPγS binding suggesting that difference in AM630 activity in different tissues is not due to species variation.

Original languageEnglish (US)
JournalLife Sciences
Volume61
Issue number9
DOIs
StatePublished - Jul 25 1997

Fingerprint

Cannabinoid Receptor Antagonists
Brain
Guinea Pigs
Cannabinoid Receptor Agonists
Vas Deferens
Ileum
iodopravadoline
Tissue
Research

Keywords

  • [S]GTPγS binding
  • Cannabinoid antagonist
  • Guinea pig

ASJC Scopus subject areas

  • Pharmacology

Cite this

Hosohata, K., Quock, R. M., Hosohata, Y., Burkey, T. H., Makriyannis, A., Consroe, P., ... Yamamura, H. I. (1997). AM630 is a competitive cannabinoid receptor antagonist in the guinea pig brain. Life Sciences, 61(9). https://doi.org/10.1016/S0024-3205(97)00596-1

AM630 is a competitive cannabinoid receptor antagonist in the guinea pig brain. / Hosohata, Keiko; Quock, Raymond M.; Hosohata, Yoshiaki; Burkey, Thomas H.; Makriyannis, Alexandros; Consroe, Paul; Roeske, William R; Yamamura, Henry I.

In: Life Sciences, Vol. 61, No. 9, 25.07.1997.

Research output: Contribution to journalArticle

Hosohata, K, Quock, RM, Hosohata, Y, Burkey, TH, Makriyannis, A, Consroe, P, Roeske, WR & Yamamura, HI 1997, 'AM630 is a competitive cannabinoid receptor antagonist in the guinea pig brain', Life Sciences, vol. 61, no. 9. https://doi.org/10.1016/S0024-3205(97)00596-1
Hosohata K, Quock RM, Hosohata Y, Burkey TH, Makriyannis A, Consroe P et al. AM630 is a competitive cannabinoid receptor antagonist in the guinea pig brain. Life Sciences. 1997 Jul 25;61(9). https://doi.org/10.1016/S0024-3205(97)00596-1
Hosohata, Keiko ; Quock, Raymond M. ; Hosohata, Yoshiaki ; Burkey, Thomas H. ; Makriyannis, Alexandros ; Consroe, Paul ; Roeske, William R ; Yamamura, Henry I. / AM630 is a competitive cannabinoid receptor antagonist in the guinea pig brain. In: Life Sciences. 1997 ; Vol. 61, No. 9.
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