Amelioration of nifedipine poisoning associated with glucagon therapy

Frank G. Walter, Gregory Frye, John T. Mullen, Brent R. Ekins, Paul A. Khasigian

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Glucagon relieves calcium channel blocker-induced hypotension in animal studies. There are no published case reports of glucagon relieving hypotension in patients with calcium channel blocker poisoning. We describe a patient who developed hypotension after ingestion of 900 mg nifedipine. Therapy with IV lactated Ringer's solution and calcium chloride alone did not relieve his hypotension. However, hypotension rapidly resolved after the addition of IV glucagon therapy. This is the first case report of glucagon therapy at least temporally associated with relief of hypotension in a patient with calcium channel blocker poisoning. More research is needed to determine the appropriate role for glucagon in treating patients with calcium channel blocker poisoning.

Original languageEnglish (US)
Pages (from-to)1234-1237
Number of pages4
JournalAnnals of emergency medicine
Volume22
Issue number7
DOIs
StatePublished - Jul 1993
Externally publishedYes

Keywords

  • glucagon nifedipine

ASJC Scopus subject areas

  • Emergency Medicine

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