An amine-derivatized, DOTA-loaded polymeric support for Fmoc solid phase peptide synthesis

Byunghee Yoo, Vipul R. Sheth, Mark D. Pagel

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

An amine-derivatized DOTA has been used to modify the surface of a polymeric support for conventional solid phase peptide synthesis (SPPS) following standard Fmoc chemistry methods. This methodology was used to synthesize a peptide-DOTA conjugate that was demonstrated to be a PARACEST MRI contrast agent. Therefore, this synthesis methodology can facilitate Fmoc SPPS of molecular imaging contrast agents.

Original languageEnglish (US)
Pages (from-to)4459-4462
Number of pages4
JournalTetrahedron Letters
Volume50
Issue number31
DOIs
StatePublished - Aug 5 2009

Keywords

  • DOTA
  • Fmoc
  • MRI
  • Molecular Imaging
  • PARACEST
  • SPPS

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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