An approach to the development of quantitative models to assess the effects of exposure to environmentally relevant levels of endocrine disrupters on homeostasis in adults

Nira Ben-Jonathan, Ralph L. Cooper, Paul Foster, Claude L. Hughes, Patricia B Hoyer, Diane Klotz, Michael Kohn, Dolores J. Lamb, George M. Stancel

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The workshop 'Characterizing the Effects of Endocrine Disrupters on Human Health at Environmental Exposure Levels' was held to provide a forum for discussions and recommendations of methods and data needed to improve risk assessments of endocrine disrupters. This article was produced by a working group charged with determining the basic mechanistic information that should be considered when designing models to quantitatively assess potential risks of environmental endocrine disrupters in adults. To reach this goal, we initially identified a set of potential organ system toxicities in males and females on the basis of known and/or suspected effects of endocrine disrupters on estrogen, androgen, and thryoid hormone systems. We used this integrated, systems-level approach because endocrine disrupters have the potential to exert toxicities at many levels and by many molecular mechanisms. Because a detailed analysis of all these untoward effects was beyond the scope of this workshop, we selected the specific end point of testicular function for a more detailed analysis. The goal was to identify the information required to develop a quantitative model(s) of the effects of endocrine disrupters on this system while focusing on spermatogenesis, sperm characteristics, and testicular steroidogenesis as specific markers. Testicular function was selected because it is a prototypical integrated end point that can be affected adversely by individual endocrine disrupters or chemical mixtures acting at one specific site or at multiple sites. Our specific objective was to gather the information needed to develop models in the adult organism containing functional homeostatic mechanisms, and for this reason we did not consider possible developmental toxicities. Homeostatic mechanisms have the potential to ameliorate or lessen the effects of endocrine disrupters, but these pathways are also potential target sites for the actions of these chemicals.

Original languageEnglish (US)
Pages (from-to)605-611
Number of pages7
JournalEnvironmental Health Perspectives
Volume107
Issue numberSUPPL. 4
StatePublished - 1999

Fingerprint

Endocrine disrupters
endocrine disruptor
homeostasis
Homeostasis
Pharmacologic Actions
Education
Environmental Exposure
Spermatogenesis
Androgens
Spermatozoa
Estrogens
Hormones
Toxicity
Health
toxicity
androgen
exposure
effect
sperm
Risk assessment

Keywords

  • Androgen
  • Endocrine disruptors
  • Estrogens
  • Homeostasis
  • Spermatogenesis
  • Testicular steroidogenesis
  • Thyroid hormones

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

Cite this

An approach to the development of quantitative models to assess the effects of exposure to environmentally relevant levels of endocrine disrupters on homeostasis in adults. / Ben-Jonathan, Nira; Cooper, Ralph L.; Foster, Paul; Hughes, Claude L.; Hoyer, Patricia B; Klotz, Diane; Kohn, Michael; Lamb, Dolores J.; Stancel, George M.

In: Environmental Health Perspectives, Vol. 107, No. SUPPL. 4, 1999, p. 605-611.

Research output: Contribution to journalArticle

Ben-Jonathan, Nira ; Cooper, Ralph L. ; Foster, Paul ; Hughes, Claude L. ; Hoyer, Patricia B ; Klotz, Diane ; Kohn, Michael ; Lamb, Dolores J. ; Stancel, George M. / An approach to the development of quantitative models to assess the effects of exposure to environmentally relevant levels of endocrine disrupters on homeostasis in adults. In: Environmental Health Perspectives. 1999 ; Vol. 107, No. SUPPL. 4. pp. 605-611.
@article{6e0f153044b44c69a04af027d9ff7e5d,
title = "An approach to the development of quantitative models to assess the effects of exposure to environmentally relevant levels of endocrine disrupters on homeostasis in adults",
abstract = "The workshop 'Characterizing the Effects of Endocrine Disrupters on Human Health at Environmental Exposure Levels' was held to provide a forum for discussions and recommendations of methods and data needed to improve risk assessments of endocrine disrupters. This article was produced by a working group charged with determining the basic mechanistic information that should be considered when designing models to quantitatively assess potential risks of environmental endocrine disrupters in adults. To reach this goal, we initially identified a set of potential organ system toxicities in males and females on the basis of known and/or suspected effects of endocrine disrupters on estrogen, androgen, and thryoid hormone systems. We used this integrated, systems-level approach because endocrine disrupters have the potential to exert toxicities at many levels and by many molecular mechanisms. Because a detailed analysis of all these untoward effects was beyond the scope of this workshop, we selected the specific end point of testicular function for a more detailed analysis. The goal was to identify the information required to develop a quantitative model(s) of the effects of endocrine disrupters on this system while focusing on spermatogenesis, sperm characteristics, and testicular steroidogenesis as specific markers. Testicular function was selected because it is a prototypical integrated end point that can be affected adversely by individual endocrine disrupters or chemical mixtures acting at one specific site or at multiple sites. Our specific objective was to gather the information needed to develop models in the adult organism containing functional homeostatic mechanisms, and for this reason we did not consider possible developmental toxicities. Homeostatic mechanisms have the potential to ameliorate or lessen the effects of endocrine disrupters, but these pathways are also potential target sites for the actions of these chemicals.",
keywords = "Androgen, Endocrine disruptors, Estrogens, Homeostasis, Spermatogenesis, Testicular steroidogenesis, Thyroid hormones",
author = "Nira Ben-Jonathan and Cooper, {Ralph L.} and Paul Foster and Hughes, {Claude L.} and Hoyer, {Patricia B} and Diane Klotz and Michael Kohn and Lamb, {Dolores J.} and Stancel, {George M.}",
year = "1999",
language = "English (US)",
volume = "107",
pages = "605--611",
journal = "Environmental Health Perspectives",
issn = "0091-6765",
publisher = "Public Health Services, US Dept of Health and Human Services",
number = "SUPPL. 4",

}

TY - JOUR

T1 - An approach to the development of quantitative models to assess the effects of exposure to environmentally relevant levels of endocrine disrupters on homeostasis in adults

AU - Ben-Jonathan, Nira

AU - Cooper, Ralph L.

AU - Foster, Paul

AU - Hughes, Claude L.

AU - Hoyer, Patricia B

AU - Klotz, Diane

AU - Kohn, Michael

AU - Lamb, Dolores J.

AU - Stancel, George M.

PY - 1999

Y1 - 1999

N2 - The workshop 'Characterizing the Effects of Endocrine Disrupters on Human Health at Environmental Exposure Levels' was held to provide a forum for discussions and recommendations of methods and data needed to improve risk assessments of endocrine disrupters. This article was produced by a working group charged with determining the basic mechanistic information that should be considered when designing models to quantitatively assess potential risks of environmental endocrine disrupters in adults. To reach this goal, we initially identified a set of potential organ system toxicities in males and females on the basis of known and/or suspected effects of endocrine disrupters on estrogen, androgen, and thryoid hormone systems. We used this integrated, systems-level approach because endocrine disrupters have the potential to exert toxicities at many levels and by many molecular mechanisms. Because a detailed analysis of all these untoward effects was beyond the scope of this workshop, we selected the specific end point of testicular function for a more detailed analysis. The goal was to identify the information required to develop a quantitative model(s) of the effects of endocrine disrupters on this system while focusing on spermatogenesis, sperm characteristics, and testicular steroidogenesis as specific markers. Testicular function was selected because it is a prototypical integrated end point that can be affected adversely by individual endocrine disrupters or chemical mixtures acting at one specific site or at multiple sites. Our specific objective was to gather the information needed to develop models in the adult organism containing functional homeostatic mechanisms, and for this reason we did not consider possible developmental toxicities. Homeostatic mechanisms have the potential to ameliorate or lessen the effects of endocrine disrupters, but these pathways are also potential target sites for the actions of these chemicals.

AB - The workshop 'Characterizing the Effects of Endocrine Disrupters on Human Health at Environmental Exposure Levels' was held to provide a forum for discussions and recommendations of methods and data needed to improve risk assessments of endocrine disrupters. This article was produced by a working group charged with determining the basic mechanistic information that should be considered when designing models to quantitatively assess potential risks of environmental endocrine disrupters in adults. To reach this goal, we initially identified a set of potential organ system toxicities in males and females on the basis of known and/or suspected effects of endocrine disrupters on estrogen, androgen, and thryoid hormone systems. We used this integrated, systems-level approach because endocrine disrupters have the potential to exert toxicities at many levels and by many molecular mechanisms. Because a detailed analysis of all these untoward effects was beyond the scope of this workshop, we selected the specific end point of testicular function for a more detailed analysis. The goal was to identify the information required to develop a quantitative model(s) of the effects of endocrine disrupters on this system while focusing on spermatogenesis, sperm characteristics, and testicular steroidogenesis as specific markers. Testicular function was selected because it is a prototypical integrated end point that can be affected adversely by individual endocrine disrupters or chemical mixtures acting at one specific site or at multiple sites. Our specific objective was to gather the information needed to develop models in the adult organism containing functional homeostatic mechanisms, and for this reason we did not consider possible developmental toxicities. Homeostatic mechanisms have the potential to ameliorate or lessen the effects of endocrine disrupters, but these pathways are also potential target sites for the actions of these chemicals.

KW - Androgen

KW - Endocrine disruptors

KW - Estrogens

KW - Homeostasis

KW - Spermatogenesis

KW - Testicular steroidogenesis

KW - Thyroid hormones

UR - http://www.scopus.com/inward/record.url?scp=0032856967&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032856967&partnerID=8YFLogxK

M3 - Article

C2 - 10421770

AN - SCOPUS:0032856967

VL - 107

SP - 605

EP - 611

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

SN - 0091-6765

IS - SUPPL. 4

ER -