An effective five-drug antiemetic combination for prevention of chemotherapy-related nausea and vomiting - Experience in eighty-four patients

John F. Kessler, David S Alberts, Patricia M. Plezia, Vicki Wilson, Judy Chase, Matti Aapro, Earl A. Surwit

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Antiemetics of known efficacy have been shown to block mainly one of three neurotransmitter receptors in the brain. A combination of antiemetics, designed specifically for outpatient use and consisting of metoclopramide, thiethylperazine, diphenhydramine, dexamethasone, and diazepam, is capable of blocking multiple sites in the emesis pathway. Eighty-four patients receiving highly emetic chemotherapy (85% received cisplatin) completed 200 trials of this five-drug combination using two similar regimens. Complete control (i.e., no nausea or vomiting) was achieved in 45% and two or fewer episodes of vomiting was experienced in 72% of these 200 trials. The mean number of vomiting episodes was 1.65, the median 1.0, and the range 0-15. Sedation was nearly universal, although no serious toxicity was encountered. Thus, this antiemetic combination designed for outpatient use proved highly effective in controlling nausea and vomiting associated with highly emetic anticancer treatment.

Original languageEnglish (US)
Pages (from-to)282-286
Number of pages5
JournalCancer Chemotherapy and Pharmacology
Volume16
Issue number3
DOIs
StatePublished - Apr 1986

Fingerprint

Chemotherapy
Antiemetics
Drug Combinations
Combination Drug Therapy
Nausea
Emetics
Vomiting
Thiethylperazine
Diphenhydramine
Metoclopramide
Neurotransmitter Receptor
Diazepam
Outpatients
Dexamethasone
Cisplatin
Toxicity
Brain
Drug Therapy

ASJC Scopus subject areas

  • Pharmacology
  • Oncology
  • Cancer Research

Cite this

An effective five-drug antiemetic combination for prevention of chemotherapy-related nausea and vomiting - Experience in eighty-four patients. / Kessler, John F.; Alberts, David S; Plezia, Patricia M.; Wilson, Vicki; Chase, Judy; Aapro, Matti; Surwit, Earl A.

In: Cancer Chemotherapy and Pharmacology, Vol. 16, No. 3, 04.1986, p. 282-286.

Research output: Contribution to journalArticle

Kessler, John F. ; Alberts, David S ; Plezia, Patricia M. ; Wilson, Vicki ; Chase, Judy ; Aapro, Matti ; Surwit, Earl A. / An effective five-drug antiemetic combination for prevention of chemotherapy-related nausea and vomiting - Experience in eighty-four patients. In: Cancer Chemotherapy and Pharmacology. 1986 ; Vol. 16, No. 3. pp. 282-286.
@article{8c299f60e2a240a68cee9ebb5504f01b,
title = "An effective five-drug antiemetic combination for prevention of chemotherapy-related nausea and vomiting - Experience in eighty-four patients",
abstract = "Antiemetics of known efficacy have been shown to block mainly one of three neurotransmitter receptors in the brain. A combination of antiemetics, designed specifically for outpatient use and consisting of metoclopramide, thiethylperazine, diphenhydramine, dexamethasone, and diazepam, is capable of blocking multiple sites in the emesis pathway. Eighty-four patients receiving highly emetic chemotherapy (85{\%} received cisplatin) completed 200 trials of this five-drug combination using two similar regimens. Complete control (i.e., no nausea or vomiting) was achieved in 45{\%} and two or fewer episodes of vomiting was experienced in 72{\%} of these 200 trials. The mean number of vomiting episodes was 1.65, the median 1.0, and the range 0-15. Sedation was nearly universal, although no serious toxicity was encountered. Thus, this antiemetic combination designed for outpatient use proved highly effective in controlling nausea and vomiting associated with highly emetic anticancer treatment.",
author = "Kessler, {John F.} and Alberts, {David S} and Plezia, {Patricia M.} and Vicki Wilson and Judy Chase and Matti Aapro and Surwit, {Earl A.}",
year = "1986",
month = "4",
doi = "10.1007/BF00293993",
language = "English (US)",
volume = "16",
pages = "282--286",
journal = "Cancer Chemotherapy and Pharmacology",
issn = "0344-5704",
publisher = "Springer Verlag",
number = "3",

}

TY - JOUR

T1 - An effective five-drug antiemetic combination for prevention of chemotherapy-related nausea and vomiting - Experience in eighty-four patients

AU - Kessler, John F.

AU - Alberts, David S

AU - Plezia, Patricia M.

AU - Wilson, Vicki

AU - Chase, Judy

AU - Aapro, Matti

AU - Surwit, Earl A.

PY - 1986/4

Y1 - 1986/4

N2 - Antiemetics of known efficacy have been shown to block mainly one of three neurotransmitter receptors in the brain. A combination of antiemetics, designed specifically for outpatient use and consisting of metoclopramide, thiethylperazine, diphenhydramine, dexamethasone, and diazepam, is capable of blocking multiple sites in the emesis pathway. Eighty-four patients receiving highly emetic chemotherapy (85% received cisplatin) completed 200 trials of this five-drug combination using two similar regimens. Complete control (i.e., no nausea or vomiting) was achieved in 45% and two or fewer episodes of vomiting was experienced in 72% of these 200 trials. The mean number of vomiting episodes was 1.65, the median 1.0, and the range 0-15. Sedation was nearly universal, although no serious toxicity was encountered. Thus, this antiemetic combination designed for outpatient use proved highly effective in controlling nausea and vomiting associated with highly emetic anticancer treatment.

AB - Antiemetics of known efficacy have been shown to block mainly one of three neurotransmitter receptors in the brain. A combination of antiemetics, designed specifically for outpatient use and consisting of metoclopramide, thiethylperazine, diphenhydramine, dexamethasone, and diazepam, is capable of blocking multiple sites in the emesis pathway. Eighty-four patients receiving highly emetic chemotherapy (85% received cisplatin) completed 200 trials of this five-drug combination using two similar regimens. Complete control (i.e., no nausea or vomiting) was achieved in 45% and two or fewer episodes of vomiting was experienced in 72% of these 200 trials. The mean number of vomiting episodes was 1.65, the median 1.0, and the range 0-15. Sedation was nearly universal, although no serious toxicity was encountered. Thus, this antiemetic combination designed for outpatient use proved highly effective in controlling nausea and vomiting associated with highly emetic anticancer treatment.

UR - http://www.scopus.com/inward/record.url?scp=0022652904&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022652904&partnerID=8YFLogxK

U2 - 10.1007/BF00293993

DO - 10.1007/BF00293993

M3 - Article

C2 - 3698169

AN - SCOPUS:0022652904

VL - 16

SP - 282

EP - 286

JO - Cancer Chemotherapy and Pharmacology

JF - Cancer Chemotherapy and Pharmacology

SN - 0344-5704

IS - 3

ER -