An efficient procedure for the demethylation of aryl-methyl ethers in optically pure unusual amino acids

Guigm Li, Dinesh Patel, Victor J. Hruby

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

An efficient procedure was developed for the removal of methyl groups from aryl methyl ethers, without racemization, in derivatives of unusual amino acids that are of significant importance in the design of highly selective peptide protein ligands with specicific conformational topographical features. Demethylation of aromatic amino acids can result in an appreciable increase in receptor affinity, hence the new mild procedure which have been developed represents a facile practical method for demethylation of Tyr (OMe) derivatives, including novel sidechain ring or C-3 modified analogs.

Original languageEnglish (US)
Pages (from-to)5393-5396
Number of pages4
JournalTetrahedron Letters
Volume34
Issue number34
DOIs
StatePublished - 1993

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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