An Electron Microscope‐Cytochemical Method for Differentiating Membranes of Host Red Cells and Malaria Parasites

THOMAS M. SEED, MASAMICHI AIKAWA, CHARLES R. STERLING

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Limiting membranes of malaria parasites and host red cells stain differently when exposed to positively charged iron colloid. Negatively charged red cell membranes avidly bind colloid, whereas parasite membranes do not. This selectivity in colloidal iron uptake by the 2 types of membranes can be utilized as an aid in discerning the amounts of contaminating host cell membranes in “free” malaria parasite preparations and in related cell‐free membrane extracts.

Original languageEnglish (US)
Pages (from-to)603-605
Number of pages3
JournalThe Journal of protozoology
Volume20
Issue number5
DOIs
StatePublished - Nov 1973

Keywords

  • Plasmodium berghei
  • colloidal iron
  • cytochemistry
  • electron microscopy
  • host erythrocytes
  • malaria parasite

ASJC Scopus subject areas

  • Parasitology

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