An electrothermal micromixer for molecular analysis

Mandy L Y Sin, Vinay Gidwani, Vincent Gau, Pak Kin Wong

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

Diffusion is often the rate-limiting step in microfluidic-based biochemical analysis systems. In this paper, an alternative current electrothermal mixer for molecular diagnostic is presented. The mixer consists of a concentric electrode design integrated in a microfluidic cartridge. We investigated the electrothermal flow by visualizing the trajectories of seeded particles. The velocity shows a fourth power voltage dependence and is most efficient in the range of 200-600 kHz. By optimizing the design and operating conditions, we demonstrated enhancement of DNA hybridization with a 60-fold reduction in total assay time.

Original languageEnglish (US)
Title of host publication4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009
Pages827-831
Number of pages5
DOIs
StatePublished - 2009
Event4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009 - Shenzhen, China
Duration: Jan 5 2009Jan 8 2009

Other

Other4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009
CountryChina
CityShenzhen
Period1/5/091/8/09

Fingerprint

Microfluidics
Assays
DNA
Trajectories
Electrodes
Electric potential

Keywords

  • Biosensor
  • Electrothermal flow
  • Fluidic manipulation
  • Lab-ona-chip
  • Micromixer

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

Cite this

Sin, M. L. Y., Gidwani, V., Gau, V., & Wong, P. K. (2009). An electrothermal micromixer for molecular analysis. In 4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009 (pp. 827-831). [5068704] https://doi.org/10.1109/NEMS.2009.5068704

An electrothermal micromixer for molecular analysis. / Sin, Mandy L Y; Gidwani, Vinay; Gau, Vincent; Wong, Pak Kin.

4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009. 2009. p. 827-831 5068704.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Sin, MLY, Gidwani, V, Gau, V & Wong, PK 2009, An electrothermal micromixer for molecular analysis. in 4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009., 5068704, pp. 827-831, 4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009, Shenzhen, China, 1/5/09. https://doi.org/10.1109/NEMS.2009.5068704
Sin MLY, Gidwani V, Gau V, Wong PK. An electrothermal micromixer for molecular analysis. In 4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009. 2009. p. 827-831. 5068704 https://doi.org/10.1109/NEMS.2009.5068704
Sin, Mandy L Y ; Gidwani, Vinay ; Gau, Vincent ; Wong, Pak Kin. / An electrothermal micromixer for molecular analysis. 4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009. 2009. pp. 827-831
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