An ethanol solvate of beclomethasone dipropionate

Philip J. Kuehl, Michael D. Carducci, Paul B. Myrdal

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Beclomethasone dipropionate (BDP) is a widely used corticosteroid formulated in metered dose inhalers (MDI) for the treatment of asthma. The crystal structure of a BDP ethanol solvate of apparent formula C 28H37ClO7·2C2H6O has been determined at 170 K. The crystal investigated in this study was grown in a 3% (w/w) saturated solution of 200-proof ethanol (EtOH) at 203 K. Under these conditions, BDP crystallizes with a channel structure that allows for the inclusion of disordered ethanol molecules. The steroid molecules are held in place through intermolecular hydrogen bonding and chlorine-chlorine interactions.

Original languageEnglish (US)
Pages (from-to)o1888-o1890
JournalActa Crystallographica Section E: Structure Reports Online
Volume59
Issue number12
DOIs
StatePublished - Dec 1 2003

    Fingerprint

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

Cite this