An ethanol solvate of beclomethasone dipropionate

Philip J. Kuehl, Michael D. Carducci, Paul B Myrdal

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Beclomethasone dipropionate (BDP) is a widely used corticosteroid formulated in metered dose inhalers (MDI) for the treatment of asthma. The crystal structure of a BDP ethanol solvate of apparent formula C 28H37ClO7·2C2H6O has been determined at 170 K. The crystal investigated in this study was grown in a 3% (w/w) saturated solution of 200-proof ethanol (EtOH) at 203 K. Under these conditions, BDP crystallizes with a channel structure that allows for the inclusion of disordered ethanol molecules. The steroid molecules are held in place through intermolecular hydrogen bonding and chlorine-chlorine interactions.

Original languageEnglish (US)
JournalActa Crystallographica Section E: Structure Reports Online
Volume59
Issue number12
DOIs
StatePublished - Dec 2003

Fingerprint

Beclomethasone
Ethanol
ethyl alcohol
Chlorine
chlorine
corticosteroids
asthma
Metered Dose Inhalers
steroids
Molecules
Hydrogen Bonding
molecules
Hydrogen bonds
Adrenal Cortex Hormones
Asthma
Crystal structure
Steroids
inclusions
dosage
Crystals

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Structural Biology

Cite this

An ethanol solvate of beclomethasone dipropionate. / Kuehl, Philip J.; Carducci, Michael D.; Myrdal, Paul B.

In: Acta Crystallographica Section E: Structure Reports Online, Vol. 59, No. 12, 12.2003.

Research output: Contribution to journalArticle

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