An evaluation of human papillomavirus testing for intermediate- and high-risk types as triage before colposcopy

Kenneth D Hatch, A. Schneider, M. W. Abdel-Nour

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

Objective: Our purpose was to evaluate the. role of testing for intermediate- and high-risk human papillomavirus by use of a hybrid capture technique for predicting which patients with abnormal Papanlcolaou smears are most likely to have squamous intraepithelial lesions or cancer. Study design: Cervical cytologic studies, hybrid capture tests, and colposcopically directed biopsies were performed on 311 women referred to the colposcopy clinics with abnormal cytologic study results. Results: There was a highly significant correlation (p < 0.0001) between a positive human papillomavirus test and the finding of squamous intraepithelial lesions or invasive cancer. The sensitivity of human papillomavirus testing to detect high-grade squamous intraepithelial lesions was 74% when It was used alone and Increased to 91% when coupled with abnormal cytologic study results of low- or high-grade squamous intraepithelial lesions or cancer. In 44 women with atypical squamous cells of undetermined significance on cytologic study, human papillomavirus testing identified six of 10 who had high-grade squamous intraepithelial lesions. For the 96 patients with low-grade squamous intraepithelial lesions, human papillomavirus testing was successful In identifying 29 of the 37 with high-grade squamous intraepithelial lesions (sensitivity 0.76). Conclusion: Testing for intermediate- and high-risk human papillomavirus types by hybrid capture improves the detection of high-grade squamous intraepithelial lesions In women with atypical squamous cells of undetermined significance and low-grade squamous intraepithelial lesions over cytologic study used alone.

Original languageEnglish (US)
Pages (from-to)1150-1157
Number of pages8
JournalAmerican Journal of Obstetrics and Gynecology
Volume172
Issue number4 I
DOIs
StatePublished - 1995

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Colposcopy
Triage
Squamous Intraepithelial Lesions of the Cervix
Neoplasms
Biopsy

Keywords

  • Colposcopy
  • Human papillomavirus
  • Hybrid capture
  • Screening
  • Triage

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

An evaluation of human papillomavirus testing for intermediate- and high-risk types as triage before colposcopy. / Hatch, Kenneth D; Schneider, A.; Abdel-Nour, M. W.

In: American Journal of Obstetrics and Gynecology, Vol. 172, No. 4 I, 1995, p. 1150-1157.

Research output: Contribution to journalArticle

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