An experimental model of headache-related pain

Rebecca M. Edelmayer, Michael H. Ossipov, Frank Porreca

Research output: Chapter in Book/Report/Conference proceedingChapter

15 Citations (Scopus)

Abstract

Migraine patients often demonstrate cutaneous allodynia, defined as a hypersensitivity of the skin to touch or mechanical stimuli that are normally innocuous. The allodynia sometimes begins intracranially and spreads, via unknown mechanisms, to extracranial regions. The goal of the study was to develop and validate a model of cutaneous allodynia triggered by dural inflammation for this aspect of pain associated with headaches. Inflammatory mediators (IM) were applied to the dura of non-anesthetized rats via previously implanted cannulas and sensory thresholds of the face and hindpaws were characterized. IM elicited robust and time-related facial and hindpaw allodynia which peaked after approximately 3 h. These effects were reminiscent of cutaneous allodynia seen in patients with migraine or other primary headache conditions, and were reversed by agents used clinically in the treatment of migraine. Facial and hindpaw allodynia associated with dural stimulation is a useful surrogate of allodynia associated with primary headache including migraine likely reflecting the development of central sensitization and may be exploited mechanistically for the development of novel therapeutic strategies for headache pain.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
Pages109-120
Number of pages12
Volume851
DOIs
StatePublished - 2012

Publication series

NameMethods in Molecular Biology
Volume851
ISSN (Print)10643745

Fingerprint

Hyperalgesia
Headache
Theoretical Models
Pain
Migraine Disorders
Skin
Sensory Thresholds
Central Nervous System Sensitization
Touch
Hypersensitivity
Inflammation
Therapeutics

Keywords

  • Central sensitization
  • Cutaneous allodynia
  • Dural inflammation
  • Headache
  • Inflammatory mediators
  • Migraine

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Edelmayer, R. M., Ossipov, M. H., & Porreca, F. (2012). An experimental model of headache-related pain. In Methods in Molecular Biology (Vol. 851, pp. 109-120). (Methods in Molecular Biology; Vol. 851). https://doi.org/10.1007/978-1-61779-561-9_7

An experimental model of headache-related pain. / Edelmayer, Rebecca M.; Ossipov, Michael H.; Porreca, Frank.

Methods in Molecular Biology. Vol. 851 2012. p. 109-120 (Methods in Molecular Biology; Vol. 851).

Research output: Chapter in Book/Report/Conference proceedingChapter

Edelmayer, RM, Ossipov, MH & Porreca, F 2012, An experimental model of headache-related pain. in Methods in Molecular Biology. vol. 851, Methods in Molecular Biology, vol. 851, pp. 109-120. https://doi.org/10.1007/978-1-61779-561-9_7
Edelmayer RM, Ossipov MH, Porreca F. An experimental model of headache-related pain. In Methods in Molecular Biology. Vol. 851. 2012. p. 109-120. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-61779-561-9_7
Edelmayer, Rebecca M. ; Ossipov, Michael H. ; Porreca, Frank. / An experimental model of headache-related pain. Methods in Molecular Biology. Vol. 851 2012. pp. 109-120 (Methods in Molecular Biology).
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