An experimental model of headache-related pain

Rebecca M. Edelmayer, Michael H. Ossipov, Frank Porreca

Research output: Chapter in Book/Report/Conference proceedingChapter

16 Scopus citations

Abstract

Migraine patients often demonstrate cutaneous allodynia, defined as a hypersensitivity of the skin to touch or mechanical stimuli that are normally innocuous. The allodynia sometimes begins intracranially and spreads, via unknown mechanisms, to extracranial regions. The goal of the study was to develop and validate a model of cutaneous allodynia triggered by dural inflammation for this aspect of pain associated with headaches. Inflammatory mediators (IM) were applied to the dura of non-anesthetized rats via previously implanted cannulas and sensory thresholds of the face and hindpaws were characterized. IM elicited robust and time-related facial and hindpaw allodynia which peaked after approximately 3 h. These effects were reminiscent of cutaneous allodynia seen in patients with migraine or other primary headache conditions, and were reversed by agents used clinically in the treatment of migraine. Facial and hindpaw allodynia associated with dural stimulation is a useful surrogate of allodynia associated with primary headache including migraine likely reflecting the development of central sensitization and may be exploited mechanistically for the development of novel therapeutic strategies for headache pain.

Original languageEnglish (US)
Title of host publicationPain Research
Subtitle of host publicationMethods and Protocols
EditorsDavid Luo
Pages109-120
Number of pages12
DOIs
StatePublished - 2012

Publication series

NameMethods in Molecular Biology
Volume851
ISSN (Print)1064-3745

Keywords

  • Central sensitization
  • Cutaneous allodynia
  • Dural inflammation
  • Headache
  • Inflammatory mediators
  • Migraine

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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    Edelmayer, R. M., Ossipov, M. H., & Porreca, F. (2012). An experimental model of headache-related pain. In D. Luo (Ed.), Pain Research: Methods and Protocols (pp. 109-120). (Methods in Molecular Biology; Vol. 851). https://doi.org/10.1007/978-1-61779-561-9_7