An implantable synthetic SPECT lesion: A bridge from phantom to reality

M. Bret Abbott, Lars R. Furenlid, Don W. Wilson, Gail D. Stevenson, James M. Woolfenden, Harrison H. Barrett

Research output: Contribution to journalArticle

Abstract

Small-animal imaging systems are often characterized using phantoms, which may not predict performance in clinical applications. An implantable synthetic SPECT lesion would facilitate characterization of lesion detectability in a living animal. Methods: Anion-exchange columns with bed volumes of 100-300 nL were constructed from medical-grade polyvinyl chloride tubing and resin. The columns were tested in an excised mouse femur and implanted in the femur of a living mouse. Imaging was performed using a prototype dual-modality SPECT/CT system. Results: Activity of 7.4-22.2 MBq (0.2-0.6 mCi) localized within the synthetic lesion. The synthetic lesions were reused multiple times. Mice tolerated the implanted columns without complications for up to 8 wk. Conclusion: A reusable, synthetic SPECT lesion was constructed and implanted in the femur of a living mouse. The synthetic lesion is useful for the development of imaging schemes and for more realistically evaluating imaging-system performance in the context of a living animal.

Original languageEnglish (US)
Pages (from-to)1796-1799
Number of pages4
JournalJournal of Nuclear Medicine
Volume48
Issue number11
DOIs
StatePublished - Nov 1 2007

Keywords

  • Implantable device
  • Phantom
  • Small-animal SPECT
  • Synthetic lesion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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