An in vitro approach to the study of target organ toxicity of drugs and chemicals

Daniel Acosta, Elsie M B Sorensen, David C. Anuforo, David B. Mitchell, Kenneth Ramos, Kenneth S. Santone, Mary Ann Smith

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

A major goal of our laboratory has been the development of primary culture systems that retain differentiated fucntions and responses characteristic of intact tissues in vivo. Specifically, we have developed cellular models of primary cultures of rat heart, liver, and kidney cells to explore the mechanisms by which drugs or chemicals may be toxic to key organs of the body and to develop new techniques by which xenobiotics may be evaluated or identified as potential toxicants to living systems. The purpose of this paper is to describe our rationale and approach to the study of target organ toxicology with in vitro cellular systems.

Original languageEnglish (US)
Pages (from-to)495-504
Number of pages10
JournalIn Vitro Cellular and Developmental Biology - Plant
Volume21
Issue number9
DOIs
StatePublished - Sep 1985
Externally publishedYes

Fingerprint

drug toxicity
Poisons
toxicology
Xenobiotics
xenobiotics
kidney cells
Drug-Related Side Effects and Adverse Reactions
toxic substances
Liver
Toxicology
hepatocytes
Toxicity
Rats
heart
Tissue
Kidney
drugs
rats
Pharmaceutical Preparations
methodology

Keywords

  • in vitro
  • target organ
  • toxicity

ASJC Scopus subject areas

  • Embryology
  • Developmental Biology
  • Cell Biology
  • Plant Science
  • Biotechnology
  • Clinical Biochemistry

Cite this

Acosta, D., Sorensen, E. M. B., Anuforo, D. C., Mitchell, D. B., Ramos, K., Santone, K. S., & Smith, M. A. (1985). An in vitro approach to the study of target organ toxicity of drugs and chemicals. In Vitro Cellular and Developmental Biology - Plant, 21(9), 495-504. https://doi.org/10.1007/BF02620841

An in vitro approach to the study of target organ toxicity of drugs and chemicals. / Acosta, Daniel; Sorensen, Elsie M B; Anuforo, David C.; Mitchell, David B.; Ramos, Kenneth; Santone, Kenneth S.; Smith, Mary Ann.

In: In Vitro Cellular and Developmental Biology - Plant, Vol. 21, No. 9, 09.1985, p. 495-504.

Research output: Contribution to journalArticle

Acosta, D, Sorensen, EMB, Anuforo, DC, Mitchell, DB, Ramos, K, Santone, KS & Smith, MA 1985, 'An in vitro approach to the study of target organ toxicity of drugs and chemicals', In Vitro Cellular and Developmental Biology - Plant, vol. 21, no. 9, pp. 495-504. https://doi.org/10.1007/BF02620841
Acosta, Daniel ; Sorensen, Elsie M B ; Anuforo, David C. ; Mitchell, David B. ; Ramos, Kenneth ; Santone, Kenneth S. ; Smith, Mary Ann. / An in vitro approach to the study of target organ toxicity of drugs and chemicals. In: In Vitro Cellular and Developmental Biology - Plant. 1985 ; Vol. 21, No. 9. pp. 495-504.
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