An integrated health risk assessment of indigenous children exposed to arsenic in Sonora, Mexico

Juan Francisco Maldonado Escalante, Diana Meza Figueroa, Ana Gabriela Dévora Figueroa, Leticia García Rico, Jefferey L Burgess, Robert Clark Lantz, Leticia Yañez Estrada, Marco Antonio Martínez Cinco, José de Jesús Balderas Cortés, Iram Mondaca Fernández, María Mercedes Meza Montenegro

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Exposure to inorganic arsenic (InAs) through drinking water, even at low to moderate concentrations, is a global public health problem. The objectives of this study were to estimate the risk ratio (HQ), cancer risk (R), and DNA damage (comet assay) of children from three indigenous Yaqui populations located in southern Sonora, Mexico, who were exposed to InAs through drinking water. A cross-sectional study was employed, and analysis of InAs in water and urine was performed via HPLC/ICP-MS. InAs levels in drinking water from Pótam, Vícam, and Cócorit were 108.2, 36.0, and 6.2 μg/L−1 respectively. Children from Pótam had arsenic concentrations in urine of 107.1 μg As L−1 compared with 40.3 μg As L−1 for the children of Cócorit. The HQ values for the children of Pótam, Vícam, and Cócorit were 16.64, 6.02, and 0.94, while the R values were 9.4E-04, 3.5E-04, and 5.7E-05, respectively. Children with the highest arsenic exposure had significantly increased DNA damage (OTM = 14.4 vs. 4.3) [p < 0.0005] which positively correlated with urinary arsenic levels (r = 0.56, p < 0.0001). In conclusion, children of Pótam and Vícam are at significant risk of developing chronic diseases and cancers associated with chronic exposure to this metalloid.

Original languageEnglish (US)
Pages (from-to)1-16
Number of pages16
JournalHuman and Ecological Risk Assessment
DOIs
StateAccepted/In press - Mar 29 2018

Fingerprint

Health risks
Arsenic
Mexico
Risk assessment
health risk
arsenic
risk assessment
Health
Potable water
Drinking Water
drinking water
urine
DNA Damage
DNA
Metalloids
Urine
damage
Comet Assay
indigenous population
Public health

Keywords

  • arsenic
  • cancer risk
  • DNA damage
  • health risk
  • urine
  • water

ASJC Scopus subject areas

  • Ecological Modeling
  • Pollution
  • Health, Toxicology and Mutagenesis

Cite this

Maldonado Escalante, J. F., Meza Figueroa, D., Dévora Figueroa, A. G., García Rico, L., Burgess, J. L., Lantz, R. C., ... Meza Montenegro, M. M. (Accepted/In press). An integrated health risk assessment of indigenous children exposed to arsenic in Sonora, Mexico. Human and Ecological Risk Assessment, 1-16. https://doi.org/10.1080/10807039.2018.1449098

An integrated health risk assessment of indigenous children exposed to arsenic in Sonora, Mexico. / Maldonado Escalante, Juan Francisco; Meza Figueroa, Diana; Dévora Figueroa, Ana Gabriela; García Rico, Leticia; Burgess, Jefferey L; Lantz, Robert Clark; Yañez Estrada, Leticia; Martínez Cinco, Marco Antonio; Balderas Cortés, José de Jesús; Mondaca Fernández, Iram; Meza Montenegro, María Mercedes.

In: Human and Ecological Risk Assessment, 29.03.2018, p. 1-16.

Research output: Contribution to journalArticle

Maldonado Escalante, JF, Meza Figueroa, D, Dévora Figueroa, AG, García Rico, L, Burgess, JL, Lantz, RC, Yañez Estrada, L, Martínez Cinco, MA, Balderas Cortés, JDJ, Mondaca Fernández, I & Meza Montenegro, MM 2018, 'An integrated health risk assessment of indigenous children exposed to arsenic in Sonora, Mexico', Human and Ecological Risk Assessment, pp. 1-16. https://doi.org/10.1080/10807039.2018.1449098
Maldonado Escalante, Juan Francisco ; Meza Figueroa, Diana ; Dévora Figueroa, Ana Gabriela ; García Rico, Leticia ; Burgess, Jefferey L ; Lantz, Robert Clark ; Yañez Estrada, Leticia ; Martínez Cinco, Marco Antonio ; Balderas Cortés, José de Jesús ; Mondaca Fernández, Iram ; Meza Montenegro, María Mercedes. / An integrated health risk assessment of indigenous children exposed to arsenic in Sonora, Mexico. In: Human and Ecological Risk Assessment. 2018 ; pp. 1-16.
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