An integrated mechanostimulation system for probing architecture based calcium signaling in HUVEC cells

M. Junkin, Y. Lu, P. Deymier, P. K. Wong

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Dynamic signal conduction in endothelial networks plays an important role in endothelial function, and characteristics of the network architecture itself are theorized to play a role in this function. We have therefore developed an integrated mechanostimulation system to create spatiotemporal stimuli including geometric cues, fluidic shear, mechanical deformation, and tunable surface stiffness for probing intercellular communication in artificial networks of human umbilical vein endothelial (HUVEC) cells. The system enables detection of architecture dependent (e.g. linear, grid, and branching patterns), spatiotemporal calcium propagation characteristics such as speed, contact length, and repeated stimulation dependence due to mechanostimulation at the single cell level.

Original languageEnglish (US)
Title of host publication2011 IEEE 24th International Conference on Micro Electro Mechanical Systems, MEMS 2011
Pages893-896
Number of pages4
DOIs
StatePublished - Apr 13 2011
Event24th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2011 - Cancun, Mexico
Duration: Jan 23 2011Jan 27 2011

Publication series

NameProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)1084-6999

Other

Other24th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2011
CountryMexico
CityCancun
Period1/23/111/27/11

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ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Mechanical Engineering
  • Electrical and Electronic Engineering

Cite this

Junkin, M., Lu, Y., Deymier, P., & Wong, P. K. (2011). An integrated mechanostimulation system for probing architecture based calcium signaling in HUVEC cells. In 2011 IEEE 24th International Conference on Micro Electro Mechanical Systems, MEMS 2011 (pp. 893-896). [5734569] (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). https://doi.org/10.1109/MEMSYS.2011.5734569