An integrative approach to the control of cancer pain

Patrick W Mantyh, Tony L. Yaksh

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter discusses how cancer pain is generated and how the sensory information it initiates is processed as it moves from sense organ to the cerebral cortex under a constantly changing molecular architecture. Topics covered include primary afferent sensory neurons, tumour properties that excite nociceptors, tumour-induced release of protons and acidosis, tumor-induced distension and destruction of sensory fibers, and central sensitization in cancer pain.

Original languageEnglish (US)
Title of host publicationThe Neurobiology of Pain: (Molecular and Cellular Neurobiology)
PublisherOxford University Press
ISBN (Print)9780191723650, 9780198515616
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

Fingerprint

Sense Organs
Central Nervous System Sensitization
Afferent Neurons
Neoplasms
Nociceptors
Sensory Receptor Cells
Acidosis
Cerebral Cortex
Protons
Cancer Pain

Keywords

  • Cancer pain
  • Nociceptors
  • Tumor cells

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Mantyh, P. W., & Yaksh, T. L. (2010). An integrative approach to the control of cancer pain. In The Neurobiology of Pain: (Molecular and Cellular Neurobiology) Oxford University Press. https://doi.org/10.1093/acprof:oso/9780198515616.003.0015

An integrative approach to the control of cancer pain. / Mantyh, Patrick W; Yaksh, Tony L.

The Neurobiology of Pain: (Molecular and Cellular Neurobiology). Oxford University Press, 2010.

Research output: Chapter in Book/Report/Conference proceedingChapter

Mantyh, PW & Yaksh, TL 2010, An integrative approach to the control of cancer pain. in The Neurobiology of Pain: (Molecular and Cellular Neurobiology). Oxford University Press. https://doi.org/10.1093/acprof:oso/9780198515616.003.0015
Mantyh PW, Yaksh TL. An integrative approach to the control of cancer pain. In The Neurobiology of Pain: (Molecular and Cellular Neurobiology). Oxford University Press. 2010 https://doi.org/10.1093/acprof:oso/9780198515616.003.0015
Mantyh, Patrick W ; Yaksh, Tony L. / An integrative approach to the control of cancer pain. The Neurobiology of Pain: (Molecular and Cellular Neurobiology). Oxford University Press, 2010.
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