An interlaboratory comparison of dosimetry for a multi-institutional radiobiological research project: Observations, problems, solutions and lessons learned

Thomas M. Seed, Shiyun Xiao, Nancy Manley, Janko Nikolich-Zugich, Jason Pugh, Marcel Van Den Brink, Yoko Hirabayashi, Koji Yasutomo, Atsushi Iwama, Shigeo Koyasu, Ivo Shterev, Gregory Sempowski, Francesca Macchiarini, Kei Nakachi, Keith C. Kunugi, Clifford G. Hammer, Lawrence A. Dewerd

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Purpose: An interlaboratory comparison of radiation dosimetry was conducted to determine the accuracy of doses being used experimentally for animal exposures within a large multi-institutional research project. The background and approach to this effort are described and discussed in terms of basic findings, problems and solutions. Methods: Dosimetry tests were carried out utilizing optically stimulated luminescence (OSL) dosimeters embedded midline into mouse carcasses and thermal luminescence dosimeters (TLD) embedded midline into acrylic phantoms. Results: The effort demonstrated that the majority (4/7) of the laboratories was able to deliver sufficiently accurate exposures having maximum dosing errors of ≤5%. Comparable rates of 'dosimetric compliance' were noted between OSL- and TLD-based tests. Data analysis showed a highly linear relationship between 'measured' and 'target' doses, with errors falling largely between 0 and 20%. Outliers were most notable for OSL-based tests, while multiple tests by 'non-compliant' laboratories using orthovoltage X-rays contributed heavily to the wide variation in dosing errors. Conclusions: For the dosimetrically non-compliant laboratories, the relatively high rates of dosing errors were problematic, potentially compromising the quality of ongoing radiobiological research. This dosimetry effort proved to be instructive in establishing rigorous reviews of basic dosimetry protocols ensuring that dosing errors were minimized.

Original languageEnglish (US)
Pages (from-to)59-70
Number of pages12
JournalInternational Journal of Radiation Biology
Volume92
Issue number2
DOIs
StatePublished - Feb 1 2016

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Keywords

  • animal models
  • dose-response curve
  • Dosimetry
  • haematology
  • ionizing
  • OSL/TLD dosimeters
  • radiation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Seed, T. M., Xiao, S., Manley, N., Nikolich-Zugich, J., Pugh, J., Van Den Brink, M., Hirabayashi, Y., Yasutomo, K., Iwama, A., Koyasu, S., Shterev, I., Sempowski, G., Macchiarini, F., Nakachi, K., Kunugi, K. C., Hammer, C. G., & Dewerd, L. A. (2016). An interlaboratory comparison of dosimetry for a multi-institutional radiobiological research project: Observations, problems, solutions and lessons learned. International Journal of Radiation Biology, 92(2), 59-70. https://doi.org/10.3109/09553002.2015.1106024