An SU-8 based fluidic immuno-spectroscopic lab-on-a-chip for rapid quantitative detection of biomolecules

Linan Jiang, Karl P. Gerhardt, Brian Myer, Yitshak Zohar, Stanley Pau

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

A 30mm-long multimode waveguide, 40μm wide and 40μm high, is fabricated on a silicon wafer using polymer SU-8 as the core and liquid buffer as the cladding. Antibodies are successfully immobilized on the SU-8 surface designated for binding target antigens dispersed in the buffer solution. Evanescent-wave spectroscopy is performed by exciting the fluorescently-labeled antigens, bound to the waveguide surface within its evanescence field, and measuring emission light intensity. This evanescent-wave biosensor detects specific molecular interaction; its output depends on antigen concentration with a sensitivity of 40 light counts per 1μg/ml.

Original languageEnglish (US)
Title of host publicationMEMS 2008 Tucson - 21st IEEE International Conference on Micro Electro Mechanical Systems
Pages204-207
Number of pages4
DOIs
StatePublished - Aug 29 2008
Event21st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2008 Tucson - Tucson, AZ, United States
Duration: Jan 13 2008Jan 17 2008

Publication series

NameProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)1084-6999

Other

Other21st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2008 Tucson
CountryUnited States
CityTucson, AZ
Period1/13/081/17/08

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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