Analysis of Endocrine Disruptors, Pharmaceuticals, and Personal Care Products in Water Using Liquid Chromatography/Tandem Mass Spectrometry

Brett J. Vanderford, Rebecca A. Pearson, David J. Rexing, Shane A Snyder

Research output: Contribution to journalArticle

380 Scopus citations

Abstract

A method has been developed for the trace analysis of 27 compounds from a diverse group of pharmaceuticals, steroids, pesticides, and personal care products. The method employs solid-phase extraction (SPE) and liquid chromatography/tandem mass spectrometry (LC/MS/ MS), using electrospray ionization (ESI) in both positive and negative modes and atmospheric pressure chemical ionization in positive mode. Unlike many previous methods, a single SPE procedure using 1 L of water coupled to a simple LC method is used for all ionization modes. Instrument detection limits for most compounds were below 1.0 pg on column with reporting limits of 1.0 ng/L in water. Recoveries for most compounds in deionized water were greater than 80%. Sulfuric acid was found to be the preferred sample preservative, and structures of all MS/MS product ions are proposed. Matrix effects from waters with a high content of treated municipal effluent were observed in both ESI modes and are discussed in the paper.

Original languageEnglish (US)
Pages (from-to)6265-6274
Number of pages10
JournalAnalytical Chemistry
Volume75
Issue number22
DOIs
Publication statusPublished - Nov 15 2003
Externally publishedYes

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ASJC Scopus subject areas

  • Analytical Chemistry

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