Analysis of Endocrine Disruptors, Pharmaceuticals, and Personal Care Products in Water Using Liquid Chromatography/Tandem Mass Spectrometry

Brett J. Vanderford, Rebecca A. Pearson, David J. Rexing, Shane A Snyder

Research output: Contribution to journalArticle

371 Citations (Scopus)

Abstract

A method has been developed for the trace analysis of 27 compounds from a diverse group of pharmaceuticals, steroids, pesticides, and personal care products. The method employs solid-phase extraction (SPE) and liquid chromatography/tandem mass spectrometry (LC/MS/ MS), using electrospray ionization (ESI) in both positive and negative modes and atmospheric pressure chemical ionization in positive mode. Unlike many previous methods, a single SPE procedure using 1 L of water coupled to a simple LC method is used for all ionization modes. Instrument detection limits for most compounds were below 1.0 pg on column with reporting limits of 1.0 ng/L in water. Recoveries for most compounds in deionized water were greater than 80%. Sulfuric acid was found to be the preferred sample preservative, and structures of all MS/MS product ions are proposed. Matrix effects from waters with a high content of treated municipal effluent were observed in both ESI modes and are discussed in the paper.

Original languageEnglish (US)
Pages (from-to)6265-6274
Number of pages10
JournalAnalytical Chemistry
Volume75
Issue number22
DOIs
StatePublished - Nov 15 2003
Externally publishedYes

Fingerprint

Endocrine Disruptors
Liquid chromatography
Mass spectrometry
Electrospray ionization
Ionization
Water
Pharmaceutical Preparations
Trace analysis
Deionized water
Pesticides
Atmospheric pressure
Effluents
Steroids
Ions
Recovery

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Analysis of Endocrine Disruptors, Pharmaceuticals, and Personal Care Products in Water Using Liquid Chromatography/Tandem Mass Spectrometry. / Vanderford, Brett J.; Pearson, Rebecca A.; Rexing, David J.; Snyder, Shane A.

In: Analytical Chemistry, Vol. 75, No. 22, 15.11.2003, p. 6265-6274.

Research output: Contribution to journalArticle

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