Analysis of oxygen transport to tumors: causes of heterogeneous tissue oxygenation

T. W. Secomb, R. Hsu, R. D. Braun, M. W. Dewhirst

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

A theoretical model was used to study the factors that contribute to the heterogeneous distribution of tissue pressure of oxygen (PO2) and the occurrence of hypoxic regions in tumors. A Green=s function method was used to predict the distribution of PO2. For purpose of comparison, further calculations were performed in which all vessels were assumed to be at the same PO2, and in which a simple Krogh cylinder model was assumed, with the same vascular density as the simulated region. Finally, the resulting data was analyzed.

Original languageEnglish (US)
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
PublisherASME
Pages487-488
Number of pages2
Volume42
ISBN (Print)0791816117
StatePublished - Dec 1 1999
Event1999 Bioengineering Conference - Big Sky, MT, USA
Duration: Jun 16 1999Jun 20 1999

Other

Other1999 Bioengineering Conference
CityBig Sky, MT, USA
Period6/16/996/20/99

    Fingerprint

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Secomb, T. W., Hsu, R., Braun, R. D., & Dewhirst, M. W. (1999). Analysis of oxygen transport to tumors: causes of heterogeneous tissue oxygenation. In American Society of Mechanical Engineers, Bioengineering Division (Publication) BED (Vol. 42, pp. 487-488). ASME.