Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors

Timothy W Secomb, Richard Hsu, Edgardo T. Ong, Joseph F. Gross, Mark W. Dewhirst

Research output: Contribution to journalArticle

173 Citations (Scopus)

Abstract

The extent of hypoxic regions in a tumor tissue depends on the arrangement, blood flow rate and blood oxygen content of microvessels, and on the tissue's oxygen consumption rate. Here, the effects of blood flow rate, blood oxygen content and oxygen consumption on hypoxic fraction are simulated theoretically, for a region whose microvascular geometry was derived from observations of a transplanted mammary andenocarcinoma (R3230AC) in a rat dorsal skin flap preparation. In the control state, arterial PO2 is 100 mmHg, consumption rate is 2.4 cm3 O2/100 g/min, and hypoxic fraction (tissue with PO2 < 3 mmHg) is 30% Hypoxia is abolished by a reduction in consumption rate of at least 30% relative to control, or an increase in flow rate by a factor of 4 or more, or an increase in arterial PO2 by a factor of 11 or more. These results suggest that reducing oxygen consumption rate may be more effective than elevating blood flow or oxygen content as a method to reduce tumor hypoxia.

Original languageEnglish (US)
Pages (from-to)313-316
Number of pages4
JournalActa Oncologica
Volume34
Issue number3
DOIs
StatePublished - 1995

Fingerprint

Oxygen
Oxygen Consumption
Neoplasms
Microvessels
Breast
Skin

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Hematology

Cite this

Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors. / Secomb, Timothy W; Hsu, Richard; Ong, Edgardo T.; Gross, Joseph F.; Dewhirst, Mark W.

In: Acta Oncologica, Vol. 34, No. 3, 1995, p. 313-316.

Research output: Contribution to journalArticle

Secomb, Timothy W ; Hsu, Richard ; Ong, Edgardo T. ; Gross, Joseph F. ; Dewhirst, Mark W. / Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors. In: Acta Oncologica. 1995 ; Vol. 34, No. 3. pp. 313-316.
@article{b695d7943e8840b6bd61c0ced8fbebfa,
title = "Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors",
abstract = "The extent of hypoxic regions in a tumor tissue depends on the arrangement, blood flow rate and blood oxygen content of microvessels, and on the tissue's oxygen consumption rate. Here, the effects of blood flow rate, blood oxygen content and oxygen consumption on hypoxic fraction are simulated theoretically, for a region whose microvascular geometry was derived from observations of a transplanted mammary andenocarcinoma (R3230AC) in a rat dorsal skin flap preparation. In the control state, arterial PO2 is 100 mmHg, consumption rate is 2.4 cm3 O2/100 g/min, and hypoxic fraction (tissue with PO2 < 3 mmHg) is 30{\%} Hypoxia is abolished by a reduction in consumption rate of at least 30{\%} relative to control, or an increase in flow rate by a factor of 4 or more, or an increase in arterial PO2 by a factor of 11 or more. These results suggest that reducing oxygen consumption rate may be more effective than elevating blood flow or oxygen content as a method to reduce tumor hypoxia.",
author = "Secomb, {Timothy W} and Richard Hsu and Ong, {Edgardo T.} and Gross, {Joseph F.} and Dewhirst, {Mark W.}",
year = "1995",
doi = "10.3109/02841869509093981",
language = "English (US)",
volume = "34",
pages = "313--316",
journal = "Acta Oncologica",
issn = "0284-186X",
publisher = "Informa Healthcare",
number = "3",

}

TY - JOUR

T1 - Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors

AU - Secomb, Timothy W

AU - Hsu, Richard

AU - Ong, Edgardo T.

AU - Gross, Joseph F.

AU - Dewhirst, Mark W.

PY - 1995

Y1 - 1995

N2 - The extent of hypoxic regions in a tumor tissue depends on the arrangement, blood flow rate and blood oxygen content of microvessels, and on the tissue's oxygen consumption rate. Here, the effects of blood flow rate, blood oxygen content and oxygen consumption on hypoxic fraction are simulated theoretically, for a region whose microvascular geometry was derived from observations of a transplanted mammary andenocarcinoma (R3230AC) in a rat dorsal skin flap preparation. In the control state, arterial PO2 is 100 mmHg, consumption rate is 2.4 cm3 O2/100 g/min, and hypoxic fraction (tissue with PO2 < 3 mmHg) is 30% Hypoxia is abolished by a reduction in consumption rate of at least 30% relative to control, or an increase in flow rate by a factor of 4 or more, or an increase in arterial PO2 by a factor of 11 or more. These results suggest that reducing oxygen consumption rate may be more effective than elevating blood flow or oxygen content as a method to reduce tumor hypoxia.

AB - The extent of hypoxic regions in a tumor tissue depends on the arrangement, blood flow rate and blood oxygen content of microvessels, and on the tissue's oxygen consumption rate. Here, the effects of blood flow rate, blood oxygen content and oxygen consumption on hypoxic fraction are simulated theoretically, for a region whose microvascular geometry was derived from observations of a transplanted mammary andenocarcinoma (R3230AC) in a rat dorsal skin flap preparation. In the control state, arterial PO2 is 100 mmHg, consumption rate is 2.4 cm3 O2/100 g/min, and hypoxic fraction (tissue with PO2 < 3 mmHg) is 30% Hypoxia is abolished by a reduction in consumption rate of at least 30% relative to control, or an increase in flow rate by a factor of 4 or more, or an increase in arterial PO2 by a factor of 11 or more. These results suggest that reducing oxygen consumption rate may be more effective than elevating blood flow or oxygen content as a method to reduce tumor hypoxia.

UR - http://www.scopus.com/inward/record.url?scp=0029035872&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029035872&partnerID=8YFLogxK

U2 - 10.3109/02841869509093981

DO - 10.3109/02841869509093981

M3 - Article

C2 - 7779415

AN - SCOPUS:0029035872

VL - 34

SP - 313

EP - 316

JO - Acta Oncologica

JF - Acta Oncologica

SN - 0284-186X

IS - 3

ER -