Analysis of thrombi retrieved from cerebral arteries of patients with acute ischemic stroke

Victor J. Marder, Dennis J. Chute, Sidney Starkman, Anna M. Abolian, Stella Kidwell, David Liebeskind, Bruce Ovbiagele, Fernando Vinuela, Gary Duckwiler, Reza Jahan, Paul M. Vespa, Scott Selco, Venkatakrishna Rajajee, Doojin Kim, Nerses Sanossian, Jeffrey L. Saver

Research output: Contribution to journalArticle

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Abstract

BACKGROUND AND PURPOSE - Information regarding the histological structure of thromboemboli that cause acute stroke provides insight into pathogenesis and clinical management. METHODS - This report describes the histological analysis of thromboemboli retrieved by endovascular mechanical extraction from the middle cerebral artery (MCA) and intracranial carotid artery (ICA) of 25 patients with acute ischemic stroke. RESULTS - The large majority (75%) of thromboemboli shared architectural features of random fibrin:platelet deposits interspersed with linear collections of nucleated cells (monocytes and neutrophils) and confined erythrocyte-rich regions. This histology was prevalent with both cardioembolic and atherosclerotic sources of embolism. "Red" clots composed uniquely of erythrocytes were uncommon and observed only with incomplete extractions, and cholesterol crystals were notably absent. The histology of thromboemboli that could not be retrieved from 29 concurrent patients may be different. No thrombus >3 mm wide caused stroke limited to the MCA, and no thrombus >5 mm wide was removed from the ICA. A mycotic embolus was successfully removed in 1 case, and a small atheroma and attached intima were removed without clinical consequence from another. CONCLUSIONS - Thromboemboli retrieved from the MCA or intracranial ICA of patients with acute ischemic stroke have similar histological components, whether derived from cardiac or arterial sources. Embolus size determines ultimate destination, those >5 mm wide likely bypassing the cerebral vessels entirely. The fibrin:platelet pattern that dominates thromboembolic structure provides a foundation for both antiplatelet and anticoagulant treatment strategies in stroke prevention.

Original languageEnglish (US)
Pages (from-to)2086-2093
Number of pages8
JournalStroke
Volume37
Issue number8
DOIs
StatePublished - Aug 2006
Externally publishedYes

Fingerprint

Cerebral Arteries
Thrombosis
Stroke
Middle Cerebral Artery
Embolism
Carotid Arteries
Fibrin
Histology
Blood Platelets
Erythrocytes
Atherosclerotic Plaques
Anticoagulants
Monocytes
Neutrophils
Cholesterol

Keywords

  • Cerebral arteries
  • Thrombi

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Marder, V. J., Chute, D. J., Starkman, S., Abolian, A. M., Kidwell, S., Liebeskind, D., ... Saver, J. L. (2006). Analysis of thrombi retrieved from cerebral arteries of patients with acute ischemic stroke. Stroke, 37(8), 2086-2093. https://doi.org/10.1161/01.STR.0000230307.03438.94

Analysis of thrombi retrieved from cerebral arteries of patients with acute ischemic stroke. / Marder, Victor J.; Chute, Dennis J.; Starkman, Sidney; Abolian, Anna M.; Kidwell, Stella; Liebeskind, David; Ovbiagele, Bruce; Vinuela, Fernando; Duckwiler, Gary; Jahan, Reza; Vespa, Paul M.; Selco, Scott; Rajajee, Venkatakrishna; Kim, Doojin; Sanossian, Nerses; Saver, Jeffrey L.

In: Stroke, Vol. 37, No. 8, 08.2006, p. 2086-2093.

Research output: Contribution to journalArticle

Marder, VJ, Chute, DJ, Starkman, S, Abolian, AM, Kidwell, S, Liebeskind, D, Ovbiagele, B, Vinuela, F, Duckwiler, G, Jahan, R, Vespa, PM, Selco, S, Rajajee, V, Kim, D, Sanossian, N & Saver, JL 2006, 'Analysis of thrombi retrieved from cerebral arteries of patients with acute ischemic stroke', Stroke, vol. 37, no. 8, pp. 2086-2093. https://doi.org/10.1161/01.STR.0000230307.03438.94
Marder, Victor J. ; Chute, Dennis J. ; Starkman, Sidney ; Abolian, Anna M. ; Kidwell, Stella ; Liebeskind, David ; Ovbiagele, Bruce ; Vinuela, Fernando ; Duckwiler, Gary ; Jahan, Reza ; Vespa, Paul M. ; Selco, Scott ; Rajajee, Venkatakrishna ; Kim, Doojin ; Sanossian, Nerses ; Saver, Jeffrey L. / Analysis of thrombi retrieved from cerebral arteries of patients with acute ischemic stroke. In: Stroke. 2006 ; Vol. 37, No. 8. pp. 2086-2093.
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T1 - Analysis of thrombi retrieved from cerebral arteries of patients with acute ischemic stroke

AU - Marder, Victor J.

AU - Chute, Dennis J.

AU - Starkman, Sidney

AU - Abolian, Anna M.

AU - Kidwell, Stella

AU - Liebeskind, David

AU - Ovbiagele, Bruce

AU - Vinuela, Fernando

AU - Duckwiler, Gary

AU - Jahan, Reza

AU - Vespa, Paul M.

AU - Selco, Scott

AU - Rajajee, Venkatakrishna

AU - Kim, Doojin

AU - Sanossian, Nerses

AU - Saver, Jeffrey L.

PY - 2006/8

Y1 - 2006/8

N2 - BACKGROUND AND PURPOSE - Information regarding the histological structure of thromboemboli that cause acute stroke provides insight into pathogenesis and clinical management. METHODS - This report describes the histological analysis of thromboemboli retrieved by endovascular mechanical extraction from the middle cerebral artery (MCA) and intracranial carotid artery (ICA) of 25 patients with acute ischemic stroke. RESULTS - The large majority (75%) of thromboemboli shared architectural features of random fibrin:platelet deposits interspersed with linear collections of nucleated cells (monocytes and neutrophils) and confined erythrocyte-rich regions. This histology was prevalent with both cardioembolic and atherosclerotic sources of embolism. "Red" clots composed uniquely of erythrocytes were uncommon and observed only with incomplete extractions, and cholesterol crystals were notably absent. The histology of thromboemboli that could not be retrieved from 29 concurrent patients may be different. No thrombus >3 mm wide caused stroke limited to the MCA, and no thrombus >5 mm wide was removed from the ICA. A mycotic embolus was successfully removed in 1 case, and a small atheroma and attached intima were removed without clinical consequence from another. CONCLUSIONS - Thromboemboli retrieved from the MCA or intracranial ICA of patients with acute ischemic stroke have similar histological components, whether derived from cardiac or arterial sources. Embolus size determines ultimate destination, those >5 mm wide likely bypassing the cerebral vessels entirely. The fibrin:platelet pattern that dominates thromboembolic structure provides a foundation for both antiplatelet and anticoagulant treatment strategies in stroke prevention.

AB - BACKGROUND AND PURPOSE - Information regarding the histological structure of thromboemboli that cause acute stroke provides insight into pathogenesis and clinical management. METHODS - This report describes the histological analysis of thromboemboli retrieved by endovascular mechanical extraction from the middle cerebral artery (MCA) and intracranial carotid artery (ICA) of 25 patients with acute ischemic stroke. RESULTS - The large majority (75%) of thromboemboli shared architectural features of random fibrin:platelet deposits interspersed with linear collections of nucleated cells (monocytes and neutrophils) and confined erythrocyte-rich regions. This histology was prevalent with both cardioembolic and atherosclerotic sources of embolism. "Red" clots composed uniquely of erythrocytes were uncommon and observed only with incomplete extractions, and cholesterol crystals were notably absent. The histology of thromboemboli that could not be retrieved from 29 concurrent patients may be different. No thrombus >3 mm wide caused stroke limited to the MCA, and no thrombus >5 mm wide was removed from the ICA. A mycotic embolus was successfully removed in 1 case, and a small atheroma and attached intima were removed without clinical consequence from another. CONCLUSIONS - Thromboemboli retrieved from the MCA or intracranial ICA of patients with acute ischemic stroke have similar histological components, whether derived from cardiac or arterial sources. Embolus size determines ultimate destination, those >5 mm wide likely bypassing the cerebral vessels entirely. The fibrin:platelet pattern that dominates thromboembolic structure provides a foundation for both antiplatelet and anticoagulant treatment strategies in stroke prevention.

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KW - Thrombi

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