Analytical approaches to investigate transmitter content and release from single secretory vesicles

Donna M. Omiatek, Ann Sofie Cans, Michael L. Heien, Andrew G. Ewing

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

The vesicle serves as the primary intracellular unit for the highly efficient storage and release of chemical messengers triggered during signaling processes in the nervous system. This review highlights conventional and emerging analytical methods that have used microscopy, electrochemistry, and spectroscopy to resolve the location, time course, and quantal content characteristics of neurotransmitter release. Particular focus is on the investigation of the synaptic vesicle and its involvement in the fundamental molecular mechanisms of cell communication.

Original languageEnglish (US)
Pages (from-to)3269-3279
Number of pages11
JournalAnalytical and bioanalytical chemistry
Volume397
Issue number8
DOIs
StatePublished - Aug 1 2010
Externally publishedYes

Keywords

  • Capillary electrophoresis
  • Carbon-fiber amperometry
  • Electrochemical cytometry
  • Exocytosis
  • Neurotransmitter
  • Vesicle

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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